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Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
A second order derivative spectrophotometric method for the determination of bifonazole in the presence of methyland propyl p-hydroxybenzoate as preservatives has been developed. The determination was performed in a 0.1 M ...
Spectrophotometric study of diclofenac-Fe(III) complex
(Pergamon-Elsevier Science Ltd, Oxford, 1997)
A multifactor optimisation technique is successfully applied to develop a new spectrophotometric method in which diclofenac sodium is analysed and determined as it's Fe(III) complex. The effect of simultaneously varying ...
Quality by Design approach in the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol and its impurities
(Elsevier Science BV, Amsterdam, 2015)
This study presents the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol, its endo-isomer and three impurities following Quality by Design (QbD) approach. The main objective ...
Use of ANN modelling in structure-retention relationships of diuretics in RP-HPLC
(Pergamon-Elsevier Science Ltd, Oxford, 1999)
Structure-retention relationship study, conducted by RP-HPLC, was used to investigate physical chemical parameters related to the RP retention times of amiloride, hydrochlorothiazide and methyldopa in order to predict the ...
The evaluation of drug-plasma protein binding interaction on immobilized human serum albumin stationary phase, aided by different computational approaches
(Elsevier B.V., 2022)
The drug-human serum albumin binding interaction was evaluated on a stationary phase immobilized with human serum albumin using a mixture of phosphate buffer (pH 7.0) and acetonitrile modifier as mobile phase. The 33 ...
Estimation of passive gastrointestinal absorption and membrane retention using PAMPA test, quantitative structure-permeability and quantitative structure-retention relationship analyses of ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid and 1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid derivatives
(Elsevier B.V., 2020)
Passive gastrointestinal absorption and membrane retention of twelve esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid (EDCP) and (S,S)-1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid (PDCP), ...
Corona Charged Aerosol Detector in studying retention and β-cyclodextrin complex stability using RP-HPLC
(Elsevier B.V., 2021)
Binding between cyclodextrin (CD) cavity and guest molecule in Reversed Phase High-Performance Liquid Chromatography (RP-HPLC) is dynamic process. In general, increasing CD concentration is inducing inclusion complex ...
Generic approach in a gradient elution HPLC method development that enables troubleshooting free method transfer
(Elsevier B.V., 2022)
Nowadays, method development is strongly focused on reducing time needed for method development and execution. This subject specially concerns gradient elution methods regarding the usual need for trouble shooting assistance ...
Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
Acid-base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton-Robinson's buffer at 25 degrees C. Acidity constant of ...
Chaotropic agents in liquid chromatographic method development for the simultaneous analysis of levodopa, carbidopa, entacapone and their impurities
(Elsevier Science BV, Amsterdam, 2013)
The simultaneous pharmaceutical analysis of multi-component drugs represents a challenge due to a large total number of analytes present in the sample. These analytes are not only the active pharmaceutical ingredients, but ...