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Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue
dc.creator | Vladimirov, S | |
dc.creator | Brborić, Jasmina | |
dc.creator | Agbaba, Danica | |
dc.creator | Zivanov, D | |
dc.creator | Stakić, D.Ž | |
dc.date.accessioned | 2019-09-02T10:48:35Z | |
dc.date.available | 2019-09-02T10:48:35Z | |
dc.date.issued | 1993 | |
dc.identifier.issn | 0014-827X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/105 | |
dc.description.abstract | A sensitive spectrophotometric method for the determination of bifonazole is described. Bifonazole was treated with bromphenol blue (BPB) in the presence of citrate buffer (pH 2.5; μ = 0.23). The formed ion-pair complex was extracted with chloroform. By using spectrophotometric measurements, Job's and Bent-French's methods, it was found that bifonazole and BPB formed an ion-pair complex with the absorption maximum at 414 nm (molecular ratio of bifonazole BPB = 1:2) and molar absorptivity 2.23 x 104 L mol-1 cm-1. Beer's law was obeyed up to 2.5 μg ml-1. The proposed method was applied for determination of bifonazole in pharmaceutical formulations. Statistical analysis of the results obtained showed that the proposed method has good reproducibility and precision. | en |
dc.rights | restrictedAccess | |
dc.source | Farmaco | |
dc.title | Spectrophotometric determination of bifonazole in pharmaceutical formulations using bromphenol blue | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Брборић, Јасмина; Владимиров, С; Aгбаба, Даница; Стакић, Д.Ж; Зиванов, Д; | |
dc.citation.volume | 48 | |
dc.citation.issue | 7 | |
dc.citation.spage | 1007 | |
dc.citation.epage | 1015 | |
dc.citation.other | 48(7): 1007-1015 | |
dc.identifier.scopus | 2-s2.0-0027254555 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_105 | |
dc.type.version | publishedVersion |
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