dc.creator | Vujić, Zorica | |
dc.creator | Uskoković-Marković, Snežana | |
dc.creator | Kuntić, Vesna | |
dc.date.accessioned | 2019-09-02T11:18:29Z | |
dc.date.available | 2019-09-02T11:18:29Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0003-2719 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1266 | |
dc.description.abstract | A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142072/RS// | |
dc.rights | restrictedAccess | |
dc.source | Analytical Letters | |
dc.subject | Antidepressants | en |
dc.subject | desipramine | en |
dc.subject | maprotiline | en |
dc.subject | moclobemide | en |
dc.subject | pharmaceutical formulations | en |
dc.subject | RP-HPLC | en |
dc.subject | statistical optimization | en |
dc.title | Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ускоковић-Марковић, Снежана; Вујић, Зорица; Кунтић, Весна; | |
dc.citation.volume | 42 | |
dc.citation.issue | 13 | |
dc.citation.spage | 2060 | |
dc.citation.epage | 2070 | |
dc.citation.other | 42(13): 2060-2070 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000269770400010 | |
dc.identifier.doi | 10.1080/00032710903082747 | |
dc.identifier.scopus | 2-s2.0-70350005086 | |
dc.type.version | publishedVersion | |