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Certain rheologycal behaviour of paracetamol solid dispersion powders
dc.creator | Tasić, Ljiljana | |
dc.creator | Pintye-Hódi, K | |
dc.date.accessioned | 2019-09-02T10:49:14Z | |
dc.date.available | 2019-09-02T10:49:14Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0006-6648 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/131 | |
dc.description.abstract | Paracetamol powder (PAR) has poor compressibility, high cohesivity and is difficult to compress. We have prepared dispersions of PAR and 3-cyclodextrin (β-CD) in physical mixture form, kneaded solid dispersion and spray dried solid dispersion (the ratio 1:1 w/w), and spray dried solid dispersion of PAR-Ethocel-Macogol 6000 (95:2:3), as well. The Theological characteristics of this dispersions were observed. The crystalline structure, size and shape of PAR dispersion powders differed from PAR alone. Consequently, they showed improvement in packing density; reductions in cohesivity (Kawakita's cohesivity constant was the lowest with kneaded solid dispersion PAR-β-CD); good flowability and angle of repose (especially with kneded solid dispersion PAR-β-CD). We also examined the rheological behaviour of tablet formulations prepared from those dispersions and found some correlation between the weight variation of tablets and the mixture flow properties. | en |
dc.publisher | Lubner Communication Srl | |
dc.rights | restrictedAccess | |
dc.source | Bollettino chimico farmaceutico | |
dc.subject | Paracetamol | en |
dc.subject | Powder rheology | en |
dc.subject | Solid dispersion | en |
dc.subject | β-cyclodextrin | en |
dc.title | Certain rheologycal behaviour of paracetamol solid dispersion powders | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Тасић, Љиљана; Пинтyе-Хóди, К; | |
dc.citation.volume | 135 | |
dc.citation.issue | 7 | |
dc.citation.spage | 401 | |
dc.citation.epage | 408 | |
dc.citation.other | 135(7): 401-408 | |
dc.identifier.scopus | 2-s2.0-0030453053 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_131 | |
dc.type.version | publishedVersion |
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