End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology
Само за регистроване кориснике
2012
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex ...interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases.
Кључне речи:
Glucocorticoids / Catecholamines / Neuropeptide Y / Thymocyte negative selection / T regulatory cells / Macrophages / Autoimmune diseases / Experimental autoimmune encephalomyelitisИзвор:
Immunologic Research, 2012, 52, 1-2, 64-80Издавач:
- Humana Press Inc, Totowa
Финансирање / пројекти:
- Пластичност имунског система током старења: имуномодулаторни потенцијал естрогена (RS-MESTD-Basic Research (BR or ON)-175050)
DOI: 10.1007/s12026-012-8275-9
ISSN: 0257-277X
PubMed: 22396175
WoS: 000303057600008
Scopus: 2-s2.0-84859917679
Институција/група
PharmacyTY - JOUR AU - Dimitrijević, Mirjana AU - Stanojević, Stanislava AU - Kustrimović, Nataša AU - Leposavić, Gordana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1737 AB - Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases. PB - Humana Press Inc, Totowa T2 - Immunologic Research T1 - End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology VL - 52 IS - 1-2 SP - 64 EP - 80 DO - 10.1007/s12026-012-8275-9 ER -
@article{ author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Kustrimović, Nataša and Leposavić, Gordana", year = "2012", abstract = "Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases.", publisher = "Humana Press Inc, Totowa", journal = "Immunologic Research", title = "End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology", volume = "52", number = "1-2", pages = "64-80", doi = "10.1007/s12026-012-8275-9" }
Dimitrijević, M., Stanojević, S., Kustrimović, N.,& Leposavić, G.. (2012). End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology. in Immunologic Research Humana Press Inc, Totowa., 52(1-2), 64-80. https://doi.org/10.1007/s12026-012-8275-9
Dimitrijević M, Stanojević S, Kustrimović N, Leposavić G. End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology. in Immunologic Research. 2012;52(1-2):64-80. doi:10.1007/s12026-012-8275-9 .
Dimitrijević, Mirjana, Stanojević, Stanislava, Kustrimović, Nataša, Leposavić, Gordana, "End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology" in Immunologic Research, 52, no. 1-2 (2012):64-80, https://doi.org/10.1007/s12026-012-8275-9 . .