Bioactivity of the extracts and compounds of Ruscus aculeatus L. and Ruscus hypoglossum L.
Samo za registrovane korisnike
2013
Autori
Hadžifejzović, NihadKukić-Marković, Jelena
Petrović, Silvana
Soković, Marina
Glamočlija, Jasmina
Stojković, Dejan
Nahrstedt, Adolf
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Here we report on the antimicrobial and antioxidant activity of several extracts of Ruscus aculeatus L. and Ruscus hypoglossum L., as well as of some compounds previously isolated from them (p-coumaric and caffeic acids, rutin). For antimicrobial activity, the microdilution technique was used against eight bacterial and five fungal strains, along with standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole). Investigated extracts and isolated compounds showed antibacterial and especially antifungal activity. In some cases this activity was better than standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole) and was more evident for some of isolated compounds. Antioxidant activity was investigated by DPPH and 2-deoxyribose assays, along with spectrophotometrical determination of total phenolics content (TPC) using Folin-Ciocalteu reagent. In DPPH test obtained SC50 values were in a range of 173-541 mu g/mL, while inhibition of 2-deoxyribose for some extracts reache...d up to maximal 50%. Results of antioxidant assays were strongly correlated with total phenolics content. The most active was the EtOAc fraction of the MeOH extract of R. aculeatus herb regarding all investigated parameters.
Ključne reči:
Ruscus aculeatus / Ruscus hypoglossum / Ruscaceae / Antimicrobial activity / Antioxidant activityIzvor:
Industrial Crops and Products, 2013, 49, 407-411Izdavač:
- Elsevier Science BV, Amsterdam
Finansiranje / projekti:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-MESTD-Basic Research (BR or ON)-173021)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.1016/j.indcrop.2013.05.036
ISSN: 0926-6690
WoS: 000324566600056
Scopus: 2-s2.0-84879559294
Institucija/grupa
PharmacyTY - JOUR AU - Hadžifejzović, Nihad AU - Kukić-Marković, Jelena AU - Petrović, Silvana AU - Soković, Marina AU - Glamočlija, Jasmina AU - Stojković, Dejan AU - Nahrstedt, Adolf PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1866 AB - Here we report on the antimicrobial and antioxidant activity of several extracts of Ruscus aculeatus L. and Ruscus hypoglossum L., as well as of some compounds previously isolated from them (p-coumaric and caffeic acids, rutin). For antimicrobial activity, the microdilution technique was used against eight bacterial and five fungal strains, along with standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole). Investigated extracts and isolated compounds showed antibacterial and especially antifungal activity. In some cases this activity was better than standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole) and was more evident for some of isolated compounds. Antioxidant activity was investigated by DPPH and 2-deoxyribose assays, along with spectrophotometrical determination of total phenolics content (TPC) using Folin-Ciocalteu reagent. In DPPH test obtained SC50 values were in a range of 173-541 mu g/mL, while inhibition of 2-deoxyribose for some extracts reached up to maximal 50%. Results of antioxidant assays were strongly correlated with total phenolics content. The most active was the EtOAc fraction of the MeOH extract of R. aculeatus herb regarding all investigated parameters. PB - Elsevier Science BV, Amsterdam T2 - Industrial Crops and Products T1 - Bioactivity of the extracts and compounds of Ruscus aculeatus L. and Ruscus hypoglossum L. VL - 49 SP - 407 EP - 411 DO - 10.1016/j.indcrop.2013.05.036 ER -
@article{ author = "Hadžifejzović, Nihad and Kukić-Marković, Jelena and Petrović, Silvana and Soković, Marina and Glamočlija, Jasmina and Stojković, Dejan and Nahrstedt, Adolf", year = "2013", abstract = "Here we report on the antimicrobial and antioxidant activity of several extracts of Ruscus aculeatus L. and Ruscus hypoglossum L., as well as of some compounds previously isolated from them (p-coumaric and caffeic acids, rutin). For antimicrobial activity, the microdilution technique was used against eight bacterial and five fungal strains, along with standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole). Investigated extracts and isolated compounds showed antibacterial and especially antifungal activity. In some cases this activity was better than standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole) and was more evident for some of isolated compounds. Antioxidant activity was investigated by DPPH and 2-deoxyribose assays, along with spectrophotometrical determination of total phenolics content (TPC) using Folin-Ciocalteu reagent. In DPPH test obtained SC50 values were in a range of 173-541 mu g/mL, while inhibition of 2-deoxyribose for some extracts reached up to maximal 50%. Results of antioxidant assays were strongly correlated with total phenolics content. The most active was the EtOAc fraction of the MeOH extract of R. aculeatus herb regarding all investigated parameters.", publisher = "Elsevier Science BV, Amsterdam", journal = "Industrial Crops and Products", title = "Bioactivity of the extracts and compounds of Ruscus aculeatus L. and Ruscus hypoglossum L.", volume = "49", pages = "407-411", doi = "10.1016/j.indcrop.2013.05.036" }
Hadžifejzović, N., Kukić-Marković, J., Petrović, S., Soković, M., Glamočlija, J., Stojković, D.,& Nahrstedt, A.. (2013). Bioactivity of the extracts and compounds of Ruscus aculeatus L. and Ruscus hypoglossum L.. in Industrial Crops and Products Elsevier Science BV, Amsterdam., 49, 407-411. https://doi.org/10.1016/j.indcrop.2013.05.036
Hadžifejzović N, Kukić-Marković J, Petrović S, Soković M, Glamočlija J, Stojković D, Nahrstedt A. Bioactivity of the extracts and compounds of Ruscus aculeatus L. and Ruscus hypoglossum L.. in Industrial Crops and Products. 2013;49:407-411. doi:10.1016/j.indcrop.2013.05.036 .
Hadžifejzović, Nihad, Kukić-Marković, Jelena, Petrović, Silvana, Soković, Marina, Glamočlija, Jasmina, Stojković, Dejan, Nahrstedt, Adolf, "Bioactivity of the extracts and compounds of Ruscus aculeatus L. and Ruscus hypoglossum L." in Industrial Crops and Products, 49 (2013):407-411, https://doi.org/10.1016/j.indcrop.2013.05.036 . .