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Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots
(Elsevier B.V., 2020)
Perennial plant Gentiana lutea L. is used worldwide for the preparation of pharmaceutical and food products. Health benefits of G. lutea roots are associated with the presence of major bitter-tasting secoiridoid gentiopicroside ...
Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature
(MDPI, 2020)
Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed ...
Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors
(Elsevier, 2020)
Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy. The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that this area of biomedical research attracts ...
Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease
(American Chemical Society, 2020)
Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that suffer from neurodegenerative disorders, are orphans from a structural point of view, and new I2-IR ligands are urgently required ...
Potential applications of NRF2 modulators in cancer therapy
(MDPI, 2020)
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1 (KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from oxidative, electrophilic, and xenobiotic ...
Evaluation of chitosan/xanthan gum polyelectrolyte complexes potential for pH-dependent oral delivery of escin
(Elsevier B.V., 2022)
Escin is an amphiphilic and weakly acidic drug that oral administration may lead to the irritation of gastric mucosa. The entrapment of escin into chitosan (CH)/xanthan gum (XG)-based polyelectrolyte complexes (PECs) can ...
Red Raspberry Seed Oil Low Energy Nanoemulsions: Influence of Surfactants, Antioxidants, and Temperature on Oxidative Stability
(MDPI, 2022)
The aim of this study was to assess and improve the oxidative stability of red raspberry seed oil–RO, a potential topical ingredient derived from food industry by-products, on its own and when incorporated in low energy ...
Pharmacogenomics in treatment of depression and psychosis: an update
(Elsevier Ltd, 2022)
Genetic factors can, to a certain extent, successfully predict the therapeutic effects, metabolism, and adverse reactions of drugs. This research field, pharmacogenomics, is well developed in oncology and is currently ...
Synergism between metformin and analgesics/vitamin B12 in a model of painful diabetic neuropathy
(Elsevier Masson s.r.l., 2022)
Metformin (a widely used antidiabetic drug) has demonstrated efficacy in models of painful diabetic neuropathy
(PDN), as well as certain clinical efficacy in relieving/preventing PDN. This study aimed to determine the ...
Two component model of microtubules – subsonic and supersonic solitary waves
(Elsevier, 2022)
This work represents a contribution to modelling nonlinear dynamics of microtubules, the basic components of the eukaryotic cytoskeleton. Their dynamics can be explained in terms of kink and antikink solitary waves. Special ...