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Nanocrystal dispersion of DK-I-56–1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance
(Elsevier B.V., 2020)
DK-I-56–1 (7‑methoxy‑2-(4‑methoxy‑d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one), a recently developed deuterated pyrazoloquinolinone, has been recognized as a lead candidate for treatment of various neuropsychiatric ...
Application of nanofat for treatment of traumatic faecal incontinence after sphincteroplasty – A pilot study
(John Wiley and Sons Inc, 2022)
Aim: The aim of this study was to investigate whether the application of nanofat contain-ing stem cells improves continence in women who had previously undergone anal sphinc-teroplasty with unsatisfactory long-term ...
Chitosan/Sodium Dodecyl Sulfate Complexes for Microencapsulation of Vitamin E and Its Release Profile— Understanding the Effect of Anionic Surfactant
(MDPI, 2021)
Microencapsulation of bioactive substances is a common strategy for their protection and release rate control. The use of chitosan (Ch) is particularly promising due to its abundance, biocompatibility, and interaction with ...
Optimization of the lyophilisation process for esomeprazole 40 mg powder for solution for injection/infusion using quality by design concept
(Elsevier, 2022)
The aim of this work was to apply the of Quality by Design concept in optimization of lyophilisation process in production of esomeprazole 40 mg powder for solution for injection/infusion. Optimization has been triggered ...
Evidence of acute phase reaction in asymptomatic dogs naturally infected with Babesia canis
(Elsevier, 2020)
Asymptomatic outdoor dogs can be carriers of Babesia canis, but data describing the development of an acute phase response (APR) are not available. We hypothesised that these dogs have a moderate APR that could be detected ...
Genomic characteristics of colistin-resistant salmonella enterica subsp. Enterica serovar infantis from poultry farms in the Republic of Serbia
(MDPI AG, 2020)
The antimicrobial susceptibility testing was conducted on 174 single isolates from poultry farms in Serbia and it was determined that seven Salmonella spp. were multidrug resistant. Sixteen serotypes were detected, but ...
Predicting drug release from diazepam FDM printed tablets using deep learning approach: Influence of process parameters and tablet surface/volume ratio
(Elsevier B.V., 2021)
The aim of this study was to apply artificial neural networks as deep learning tools in establishing a model for understanding and prediction of diazepam release from fused deposition modeling (FDM) printed tablets. Diazepam ...
Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets
(Elsevier B.V., 2020)
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. ...
The environmental impact of potassium tungstophosphate/ZSM-5 zeolite: Insight into catalysis and adsorption processes
(Elsevier B.V., 2021)
Environmental implementation of novel composite materials comprising potassium tungstophosphate (KPW) and ZSM-5 zeolite was tested in ethene production and pesticide removal. The study revealed that the binding of KPW to ...
Physiological behavior during stress anticipation across different chronic stress exposure adaptive models
(Taylor and Francis Ltd., 2021)
Anticipation of stress induces physiological, behavioral and cognitive adjustments that are required for an appropriate response to the upcoming situation. Additional research examining the response of cardiopulmonary ...