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Gradient Boosted Tree model: A fast track tool for predicting the Atmospheric Pressure Chemical Ionization-Mass Spectrometry signal of antipsychotics based on molecular features and experimental settings
(Elsevier B.V., 2022)
Predicting the response signal in Atmospheric Pressure Chemical Ionization - Mass Spectrometry (APCI-MS) systems appears to be considerably challenging due to a gap in knowledge of governing factors and nature of their ...
Deciphering the spatio-temporal expression and stress regulation of Fam107B, the paralog of the resilience-promoting protein DRR1 in the mouse brain
(Elsevier Ltd, 2015)
Understanding the molecular mechanisms that promote stress resilience might open up new therapeutic avenues to prevent stress-related disorders. We recently characterized a stress and glucocorticoid-regulated gene, ...
Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets
(Elsevier B.V., 2020)
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. ...
Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs
(Elsevier Science BV, Amsterdam, 2016)
Tocopherols and tocotrienols belong to the family of vitamin E (VE) with the well-known antioxidant properties. For certain alpha-tocopherol and gamma-tocotrienol derivatives used as the lead compounds in this study, ...
Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties
(Wiley, Hoboken, 2017)
ObjectivesAs there are no previous studies of the European wild-garlic (Allium ursinum) effects on the gastrointestinal system, despite its traditional applications in gastrointestinal disorders' treatment and regular use ...
Application of the design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactions
(Elsevier Science BV, Amsterdam, 2016)
This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to ...
Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor
(Applied Microbiology and Biotechnology, 1995)
The production of anthraquinones by Frangula alnus Mill. plant cells was used as a model system to evaluate the performance of a liquid-liquid extractive product-recovery process. The shake flask experiments have shown ...
Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination
(Elsevier Masson SAS, 2005)
The simple and rapid RP-HPLC method, for the simultaneous determination of lidocaine and cetrimonium bromide in the presence of pellet color corrigent, was developed. Separations were performed on a Beckman Ultrasphere ODS ...
Determination of all pK(a) values of some di- and tri-carboxylic unsaturated and epoxy acids and their polylinear correlation with the carboxylic group atomic charges
(Scientific Reviews Ltd., 2003)
For a series of seven unsaturated and seven epoxy di- and tricarboxylic acids, pK(a)(a) values were determined potentiometrically in aqueous media at 25 degreesC and an ionic strength of 0.1 M (NaCl). The thermodynamic ...
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats
(Elsevier Science BV, Amsterdam, 2016)
The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated ...