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Chemometrical evaluation of ropinirole and its impurity's chromatographic behavior
(Elsevier Science BV, Amsterdam, 2009)
The aim of this study was the chemometrical evaluation of ropinirole and its impurity's (4-[2(dipropylamino)ethyl]-1H-indol-2,3-dione) chromatographic behavior in systematic and the most efficient way. For that purpose, ...
Dynamic states of the Bray-Liebhafsky reaction when sulfuric acid is the control parameter
(Maik Nauka/Interperiodica/Springer, New York, 2009)
Dynamic behavior of hydrogen peroxide decomposition catalyzed by iodate and hydrogen ions (the Bray-Liebhafsky reaction), in a continuous stirred tank reactor is investigated. The experimental results are obtained at one ...
Design and QSAR study of analogs of gamma-tocotrienol with enhanced anti proliferative activity against human breast cancer cells
(Elsevier Science Inc, New York, 2009)
Quantitative structure-activity relationships (QSAR) study has been performed for two sets of the antitumor drugs against human breast cancer MCF-7 cell lines, alpha-tocopherol and cholesterol derivatives. Constitutional, ...
Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method
(Elsevier Science BV, Amsterdam, 2009)
The objective of the present study was to report the stability profile of novel antimigrain drug Eletriptan hydrobromide based on the information obtained from forced degradation studies. The drug was subjected to acid ...
Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk
(Elsevier Science Inc, New York, 2009)
Background and Aims. Lipoprotein (a) [Lp(a)] consists of low-density lipoprotein (LDL) and apolipoprotein (a) [apo(a)]. Both Lp(a) constituents are well-recognized risk factors for coronary artery disease (CAD). This study ...
Cytogenetic effects of 8-Cl-cAMP on human and animal chromosomes
(Balkan Union of Oncology (B.U.ON.), 2009)
Purpose: To assess the cytogenetic effects in vitro and in vivo of a non-cytotoxic antitumor agent with biomodulator activity, 8-chloro-3', 5' cyclic adenosine monophosphate (8-Cl-cAMP). Materials and methods: Cytogenetic ...
The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain
(General Physiol And Biophysics, Bratislava, 2009)
The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats ...
The role of therapeutic drug monitoring in optimazing pharmacotherapy of selected antiepileptics
(Elsevier Science BV, Amsterdam, 2009)
Synthesis of 4-Aryl-2-aminopyridine Derivatives and Related Compounds
(Taylor & Francis Inc, Philadelphia, 2009)
A short, efficient, and high-yielding synthesis of 4-aryl-2-aminopyridine derivatives has been developed. The route employs two palladium-catalyzed processes, the Suzuki reaction and the Buchwald-Hartwig amination, as the ...
Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats
(John Wiley & Sons Ltd, Chichester, 2009)
Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated ...