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Pharmacokinetics and Efficacy of Fluvoxamine and Amitriptyline in Depression
(Japanese Pharmacological Soc, Kyoto, 2009)
Although often necessary for obtaining remission following major depressive disorder, combined antidepressant treatment Is frequently associated with drug interactions and enhanced adverse drug effects. We investigated ...
Nicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass grafts
(Japanese Pharmacological Soc, Kyoto, 2015)
As we previously demonstrated the role of different K+ channels in the action of nicorandil on human saphenous vein (HSV) and human internal mammary artery (HIMA), this study aimed to analyse the contribution of the cGMP ...
A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol
(Japanese Pharmacological Soc, Kyoto, 2008)
Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of ...
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
(Japanese Pharmacological Soc, Kyoto, 2006)
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100-1000 ...
Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft
(Elsevier B.V., 2019)
Cardioprotective abilities of procyanidins, might, at least in part, attribute to their vasodilator properties. The present study was undertaken to assess the vasorelaxant effect of procyanidin B2 on isolated human saphenous ...
Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates
(Japanese Pharmacological Soc, Kyoto, 2014)
The purpose of the study was to compare peak (C-peak) and trough (C-trough) amikacin levels after twice-daily (TD) or once-daily dosing (OD) in full-term neonates. Additionally, the study aimed to address amikacin ...