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Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients
(Medecine Et Hygiene, Geneva 4, 1996)
Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen ...
When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.
(European Journal of Drug Metabolism and Pharmacokinetics, 1991)
Special interest in alternative approach to clinical pharmacokinetic research nowadays, especially in pediatric practice, is concerned on biological fluids obtainable by non- invasive methodology. Saliva and urine are the ...
An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets
(Medecine Et Hygiene, Geneva 4, 1998)
The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various ...