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Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells
(Elsevier, 2023)
Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained ...
Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different
(Elsevier B.V., 2023)
The current study aimed to examine the effect of toxic metal(oid) mixtures (lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), cadmium (Cd), chromium (Cr), and nickel (Ni)) on female reproductive function in Wistar rats ...
Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans
(Elsevier Ltd, 2023)
Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response ...
Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A
(Elsevier B.V., 2023)
Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative ...
New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
(Elsevier Inc, 2023)
The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per ...
Integration of epigenetic regulatory mechanisms in heart failure
(Springer Science and Business Media Deutschland GmbH, 2023)
The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with ...
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors
(Elsevier, 2023)
An X-ray structure of a CLICK chemistry-based BET PROTAC bound to BRD2(BD2) inspired synthesis of JQ1 derived heterocyclic amides. This effort led to the discovery of potent BET inhibitors displaying overall improved ...
The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia
(John Wiley and Sons Inc, 2023)
Aims: CYP2C19 transgenic mouse expresses the human CYP2C19 gene in the liver and developing brain, and it exhibits altered neurodevelopment associated with impairments in emotionality and locomotion. Because the validation ...
Multiomics tools for improved atherosclerotic cardiovascular disease management
(Elsevier Ltd, 2023)
Multiomics studies offer accurate preventive and therapeutic strategies for atherosclerotic cardiovascular disease (ASCVD) beyond traditional risk factors. By using artificial intelligence (AI) and machine learning (ML) ...
Call for participation in the AtheroNET COST Action to implement multiomics in atherosclerotic cardiovascular disease research
(Oxford University Press, 2023)