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Now showing items 221-227 of 227
Local scaling of the flux for standardlike maps
(American Physical Society, 2002)
Results of systematic numerical explorations of local scaling of the flux near a critical invariant circle for a class of standardlike maps are reported. The scaling law is universal and the universality class is determined ...
Sirtuins as molecular targets, mediators, and protective agents in metal‑induced toxicity
(Springer, 2021)
Metal dyshomeostasis, and especially overexposure, is known to cause adverse health effects due to modulation of a variety of metabolic pathways. An increasing body of literature has demonstrated that metal exposure may ...
Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study
(Elsevier B.V., 2022)
The main objective of this research was to conduct a dose–response modeling between the internal dose of measured blood Cd, As, Hg, Ni, and Cr and hormonal response of serum testosterone, luteinizing hormone (LH), and ...
The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid Receptors
(Lippincott Williams & Wilkins, Philadelphia, 2015)
BACKGROUND: Many clinical pain states that are difficult to treat share a common feature of sensitization of nociceptive pathways. Drugs that could normalize hyperexcitable neural activity (e.g., antiepileptic drugs) may ...
The Effects of Levetiracetam, Sumatriptan, and Caffeine in a Rat Model of Trigeminal Pain: Interactions in 2-Component Combinations
(Lippincott Williams & Wilkins, Philadelphia, 2015)
BACKGROUND: Levetiracetam is an antiepileptic drug with analgesic efficacy shown in pain models and small clinical trials. Sumatriptan is used in acute migraine treatment. Caffeine is widely consumed in some beverages/foods ...
Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining
(Elsevier, 2021)
This in silico toxicogenomic analysis aims to: (i) testify the hypothesis about the influence of the environmentally
relevant toxic metals (lead, methylmercury (organic form of mercury), cadmium and arsenic) on ...
The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders
(Elsevier B.V., 2021)
The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those ...