Приказ основних података о документу
Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety
dc.creator | Angelova, Violina T. | |
dc.creator | Vassilev, Nikolay G. | |
dc.creator | Nikolova-Mladenova, Boryana | |
dc.creator | Vitas, Jasmina | |
dc.creator | Malbasa, Radomir | |
dc.creator | Momekov, Georgi | |
dc.creator | Đukić, Mirjana | |
dc.creator | Saso, Luciano | |
dc.date.accessioned | 2019-09-02T11:56:27Z | |
dc.date.available | 2019-09-02T11:56:27Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1054-2523 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2760 | |
dc.description.abstract | A series of new hybrid molecules with a hydrazone fragment were synthesized and characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, and elemental analysis. The nuclear magnetic resonance spectra of the hydrazones 4a-c showed exchange of syn and antiperiplanar conformers around the amide bond, the more stable being the antiperiplanar one. The nuclear Overhauser effect spectroscopy (NOESY) spectra confirm E configuration around C=N bond. The tested compounds exhibited concentration-dependent cytotoxic effects against human tumor cell lines in a micromolar range (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay). Hydrazone 4a proved to be the most potent antiproliferative agent of the series. Within the antioxidant screening 8b exhibited the highest radical scavenging activity (% RSA max) and the largest rate constant for the reaction with 2,2-diphenyl-1-picrylhydrazyl. | en |
dc.publisher | Springer Birkhauser, New York | |
dc.relation | National Research Fund of Bulgaria - UNA-17/2005 | |
dc.rights | restrictedAccess | |
dc.source | Medicinal Chemistry Research | |
dc.title | Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вассилев, Николаy Г.; Ђукић, Мирјана; Малбаса, Радомир; Витас, Јасмина; Сасо, Луциано; Николова-Младенова, Борyана; Момеков, Георги; Aнгелова, Виолина Т.; | |
dc.citation.volume | 25 | |
dc.citation.issue | 9 | |
dc.citation.spage | 2082 | |
dc.citation.epage | 2092 | |
dc.citation.other | 25(9): 2082-2092 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000385175500030 | |
dc.identifier.doi | 10.1007/s00044-016-1661-4 | |
dc.identifier.scopus | 2-s2.0-84979586929 | |
dc.type.version | publishedVersion |