dc.creator | Topić, Aleksandra | |
dc.creator | Francuski, Đorđe | |
dc.creator | Nikolić, Aleksandra | |
dc.creator | Milošević, Katarina | |
dc.creator | Jovičić, Snežana | |
dc.creator | Marković, Bojan | |
dc.creator | Đukić, Mirjana | |
dc.creator | Radojković, Dragica | |
dc.date.accessioned | 2019-09-02T11:58:17Z | |
dc.date.available | 2019-09-02T11:58:17Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1551-3815 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2833 | |
dc.description.abstract | Introduction: The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. Materials and Methods: The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn-superoxide dismutase (Cu, Zn-SOD) in serum. Results: Logistic regression analysis revealed that female gender, tobacco smoke exposure, and increased 8-oxodG/creatinine were associated with risk for intermittent asthma, while the positive allergy test and increased Cu, Zn-SOD were associated with eczema in asthmatic children. Higher MPO (p = 0.033), and percent of granulocytes (p = 0.030) were found in severe persistent asthma in comparison to intermittent or mild persistent asthma. Conclusion: The main findings that TSE-induced oxidative stress is a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS// | |
dc.rights | restrictedAccess | |
dc.source | Fetal and Pediatric Pathology | |
dc.title | The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Милошевић, Катарина; Ђукић, Мирјана; Марковић, Бојан; Топић, Aлександра; Радојковић, Драгица; Николић, Aлександра; Француски, Ђорђе; Јовичић, Снежана; | |
dc.citation.volume | 36 | |
dc.citation.issue | 4 | |
dc.citation.spage | 294 | |
dc.citation.epage | 303 | |
dc.citation.other | 36(4): 294-303 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000416502700004 | |
dc.identifier.doi | 10.1080/15513815.2017.1315199 | |
dc.identifier.pmid | 28481134 | |
dc.identifier.scopus | 2-s2.0-85019046891 | |
dc.type.version | publishedVersion | |