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Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
dc.creator | Parojčić, Jelena | |
dc.creator | Đurić, Zorica | |
dc.creator | Jovanović, M | |
dc.creator | Ibrić, Svetlana | |
dc.creator | Nikolić, L | |
dc.date.accessioned | 2019-09-02T10:53:41Z | |
dc.date.available | 2019-09-02T10:53:41Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0012-6683 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/304 | |
dc.description.abstract | Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape. | en |
dc.publisher | Editio Cantor Verlag GmbH | |
dc.rights | restrictedAccess | |
dc.source | Drugs Made in Germany | |
dc.subject | Acetylsalicylic acid | en |
dc.subject | CAS 103-90-2 | en |
dc.subject | CAS 50-78-2 | en |
dc.subject | Dissolution testing | en |
dc.subject | Paracetamol | en |
dc.subject | Tablets | en |
dc.subject | experimental design | en |
dc.subject | factorial design | en |
dc.title | Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јовановић, М; Паројчић, Јелена; Ђурић, Зорица; Ибрић, Светлана; Николић, Л; | |
dc.citation.volume | 44 | |
dc.citation.issue | 1 | |
dc.citation.spage | 19 | |
dc.citation.epage | 24 | |
dc.citation.other | 44(1): 19-24 | |
dc.identifier.scopus | 2-s2.0-0035075857 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_304 | |
dc.type.version | publishedVersion |
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