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Biocompatible nanoemulsions as a tool for preclinical testing of CW-02-79, a pyrazoloquinolinone modulator of sigma-2 receptors: preformulation and formulation studies
(4th European Conference on Pharmaceutics, 20 - 21 March 2023, Marseille, France, 2023)
INTRODUCTION
Recently, the modulation of sigma-2 receptors localized in the brain is proposed to be linked with regulation of mood, anxiety, and cognition [1]. Hence, we hypothesized that novel patent-protected ligand of ...
Design of tailor-made biocompatible nanocarrier for novel pyrazoloquinolinone ligand (CW-02-79) based on comprehensive evaluation of critical physicochemical descriptors
(International Association of Physical Chemists, 2023)
Design of tailor-made biocompatible nanocarrier for novel pyrazoloquinolinone ligand (CW-02-79) based on comprehensive evaluation of critical physicochemical descriptors
Tijana Stanković1, Tanja Ilić1, Ivana Pantelić1, ...
Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation
(International Society of Drug Delivery Sciences and Technology (APGI)International Association for Pharmaceutical Technology (APV)Italian Society of Technology and Legislation (S.T.E.L.F), 2024)
The low aqueous and oil solubility of the novel
pyrazoloquinolinone ligand (CW-02-79) with significant
binding affinity for sigma-2 receptors in the brain hinders
the development of conventional parenteral formulations
and ...
Overcoming the low solubility of novel pyrazoloquinolinone ligand (CW-02-79) by combination of drug-phospholipid complex and nanoemulsion technology: design and physicochemical evaluation
(2024)
The low aqueous and oil solubility of the novelpyrazoloquinolinone ligand (CW-02-79) with significantbinding affinity for sigma-2 receptors in the brain hindersthe development of conventional parenteral formulationsand ...