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New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies
dc.creator | Antonijević Nikolić, Mirjana | |
dc.creator | Dražić, Branka | |
dc.creator | Beata, Cristóvão | |
dc.creator | Bartyzel, Agata | |
dc.creator | Miroslaw, Barbara | |
dc.creator | Tanasković, Slađana | |
dc.date.accessioned | 2022-07-05T12:42:41Z | |
dc.date.available | 2022-07-05T12:42:41Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0022-2860 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4193 | |
dc.description.abstract | New cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general formula [Cu2(L)tpmc](ClO4)4∙Y, (1): L=glycine, Y=2H2O and (2): L=alanine, Y=CH3CN were synthesized. Characterization of the complexes was performed by elemental analysis (C, H, N, Cu), UV/Vis, FTIR spectroscopy and magnetic measurements. The single crystal X-ray analyses results show that reported compounds were obtained as hydrates with formulae [Cu2(gly)tpmc](ClO4)4⋅6.5H2O (M1) and [Cu2(ala)tpmc](ClO4)4⋅5H2O (M2). They crystallize in the orthorhombic system, P212121 space group. The metal centers are bridged by the carboxylate group of the glycine/alanine and bound via nitrogen atoms of tmpc. In the complex M1/M2, geometry around Cu(II) coordination sphere is square pyramidal (M1: τ5 = 0.10/0.33; M2: τ5 = 0.04/0.30). In the crystal structure of M1 and M2 the amino acids exist as a zwitterion. The temperature dependence of magnetic susceptibility indicated very weak ferromagnetic interaction between two Cu(II) ions. The antiproliferative effect of the complexes, the free ligands, and cis-platin, as referent cytostatic drug, were tested against human leukemia monocytic cell line (THP-1), leukemic T cell lymphoblast (JURKAT) and Human Caucasian Burkitt′s lymphoma (RAMOS). The IC50 values for the complexes were from 37.9 ± 2.6 to 63.05 ± 0.72 µM. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier B.V. | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Molecular Structure | sr |
dc.subject | Cu(II) complexes | sr |
dc.subject | Octaazamacrocycle | sr |
dc.subject | Antiproliferative activity | sr |
dc.subject | Glycine and alanine | sr |
dc.title | New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.volume | 1252 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000744735400014 | |
dc.identifier.doi | 10.1016/j.molstruc.2021.131969 | |
dc.identifier.scopus | 2-s2.0-85121210625 | |
dc.type.version | publishedVersion | sr |