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Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer
dc.creator | Živanović, L | |
dc.creator | Ivanović, I | |
dc.creator | Vladimirov, S | |
dc.creator | Zečević, Mira | |
dc.date.accessioned | 2019-09-02T10:59:30Z | |
dc.date.available | 2019-09-02T10:59:30Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 1570-0232 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/535 | |
dc.description.abstract | The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.rights | restrictedAccess | |
dc.source | Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences | |
dc.subject | optimization | en |
dc.subject | cefuroxime axetil | en |
dc.subject | anti-cefuroxime axetil | en |
dc.title | Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ивановић, И; Живановић, Л; Зечевић, Мира; Владимиров, С; | |
dc.citation.volume | 800 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 175 | |
dc.citation.epage | 179 | |
dc.citation.other | 800(1-2): 175-179 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000187954500024 | |
dc.identifier.doi | 10.1016/j.jchromb.2003.08.046 | |
dc.identifier.pmid | 14698252 | |
dc.identifier.scopus | 2-s2.0-0346155970 | |
dc.type.version | publishedVersion |