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The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine
dc.creator | Vučinić-Milanković, Nada | |
dc.creator | Savić, Snežana | |
dc.creator | Vuleta, Gordana | |
dc.creator | Vučinić, Slavica | |
dc.date.accessioned | 2019-09-02T11:10:16Z | |
dc.date.available | 2019-09-02T11:10:16Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0363-9045 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/950 | |
dc.description.abstract | Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and sorbitan stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug-diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and theological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.rights | restrictedAccess | |
dc.source | Drug Development and Industrial Pharmacy | |
dc.subject | liquid-crystalline gel network | en |
dc.subject | cetearyl alcohol & cetearyl glycoside | en |
dc.subject | sorbitan stearate & sucrose cocoate | en |
dc.subject | diclophenac diethylamine release | en |
dc.subject | rheology | en |
dc.subject | droplet size analysis | en |
dc.title | The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вучинић-Миланковић, Нада; Вучинић, Славица; Савић, Снежана; Вулета, Гордана; | |
dc.citation.volume | 33 | |
dc.citation.issue | 3 | |
dc.citation.spage | 221 | |
dc.citation.epage | 234 | |
dc.citation.other | 33(3): 221-234 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000246014400002 | |
dc.identifier.doi | 10.1080/03639040601150179 | |
dc.identifier.pmid | 17454055 | |
dc.identifier.scopus | 2-s2.0-34247475216 | |
dc.type.version | publishedVersion |