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Neonatal testosterone imprinting affects thymus development and leads to phenotypic rejuvenation and masculinization of the peripheral blood T-cell compartment in adult female rats
(Academic Press Inc Elsevier Science, San Diego, 2009)
Exposure of female rodents to testosterone in the critical neonatal period produces defeminization/masculinization of the hypothalamo-pituitary-gonadal (HPG) axis, i.e. neonatal androgenization and postpones axis maturation. ...
Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro
(Pergamon-Elsevier Science Ltd, Oxford, 2018)
Manuka honey has been widely researched regarding its biological properties, in particular its antimicrobial and antioxidant capacities. We tested the genotoxic and genoprotective properties of Manuka honey, ranging from ...
Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients
(Wiley, Hoboken, 2019)
Aims CYP2D6*9, CYP2D6*10 and CYP2D6*41 are the most frequent reduced-function CYP2D6 alleles in Caucasians. Despite lacking in vivo evidence, they are collectively classified with an enzyme activity score of 0.5. Thus, the ...
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics
(American Chemical Society, 2022)
Considerations of binding pocket dynamics are one of the crucial aspects of the rational design of binders. Identification of alternative conformational states or cryptic subpockets could lead to the discovery of completely ...
Comparison of AQbD and grid point search methodology in the development of micellar HPLC method for the analysis of cilazapril and hydrochlorothiazide dosage form stability
(Elsevier Science BV, Amsterdam, 2019)
The development of stability-indicating method with isocratic elution mode based on micellar liquid chromatography for the analysis of cilazapril, hydrochlorothiazide and their degradation products was the primary aim of ...
Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz
(Oxford Univ Press Inc, Cary, 2018)
Background. A monthly treatment course of dihydroartemisinin-piperaquine (DHA-PQ) effectively prevents malaria during pregnancy. However, a drug-drug interaction pharmacokinetic (PK) study found that pregnant human ...
Effects of a novel inverse agonist selective for alpha5 GABAA receptors on spatial memory: comparison with the standard non-selective inverse agonist DMCM
(Elsevier Science BV, Amsterdam, 2008)
Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium
(Elsevier Ireland Ltd, Clare, 2008)
Gelation behavior, drug solubilization capacity and release kinetics of poloxamer 407 aqueous solutions: The combined effect of copolymer, cosolvent and hydrophobic drug
(Elsevier B.V., 2020)
The study elucidated the combined effect of the formulation parameters (the relative contents of the copolymer (poloxamer 407 (P407)), the cosolvent (isopropyl alcohol), and the hydrophobic drug (ibuprofen)) on gelation, ...
Determination of metal content in some herbal drugs - Empirical and chemometric approach
(Elsevier Science BV, Amsterdam, 2005)
The concentrations of Cu, Zn, Mn, Fe, K, Ca, Mg, Al, Ba and B in 26 herbal drugs of special importance in phytopharmacywere studied. Flame atomic absorption and emission spectrometry (FAAS, FAES), as well as inductively ...