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Prikaz rezultata 1-10 od 846
Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL
(MDPI, 2022)
Compelling evidence supports the causative link between increased levels of low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) development. For that reason, the principal aim of ...
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics
(American Chemical Society, 2022)
Considerations of binding pocket dynamics are one of the crucial aspects of the rational design of binders. Identification of alternative conformational states or cryptic subpockets could lead to the discovery of completely ...
Comparison of AQbD and grid point search methodology in the development of micellar HPLC method for the analysis of cilazapril and hydrochlorothiazide dosage form stability
(Elsevier Science BV, Amsterdam, 2019)
The development of stability-indicating method with isocratic elution mode based on micellar liquid chromatography for the analysis of cilazapril, hydrochlorothiazide and their degradation products was the primary aim of ...
Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz
(Oxford Univ Press Inc, Cary, 2018)
Background. A monthly treatment course of dihydroartemisinin-piperaquine (DHA-PQ) effectively prevents malaria during pregnancy. However, a drug-drug interaction pharmacokinetic (PK) study found that pregnant human ...
Effects of a novel inverse agonist selective for alpha5 GABAA receptors on spatial memory: comparison with the standard non-selective inverse agonist DMCM
(Elsevier Science BV, Amsterdam, 2008)
Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium
(Elsevier Ireland Ltd, Clare, 2008)
Performance comparison of nonlinear and linear regression algorithms coupled with different attribute selection methods for quantitative structure - retention relationships modelling in micellar liquid chromatography
(Elsevier, 2020)
In micellar liquid chromatography (MLC), the addition of a surfactant to the mobile phase in excess is accompanied by an alteration of its solubilising capacity and a change in the stationary phase’s properties. As an ...
Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes in Alzheimer disease patients
(Elsevier Ireland Ltd, Clare, 2006)
Premature centromere division (PCD) of the chromosome 18 was analyzed by using fluorescent in situ hybridization (FISH) on interphase peripheral blood lymphocytes isolated from six sporadic Alzheimer disease (AD) patients ...
Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system
(Springer Heidelberg, Heidelberg, 2005)
A simple and reliable kinetic method for the determination of hesperidin (Hesp) is developed. It is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system which is in a stable ...
Body mass index is independently associated with xanthine oxidase activity in overweight/obese population
(Springer International Publishing, 2020)
Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants ...