Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis
Samo za registrovane korisnike
2001
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.
Izvor:
Journal of Pharmaceutical and Biomedical Analysis, 2001, 24, 5-6, 993-998Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/S0731-7085(00)00531-8
ISSN: 0731-7085
PubMed: 11248493
WoS: 000167764200028
Scopus: 2-s2.0-0035089540
Institucija/grupa
PharmacyTY - JOUR AU - Marinković, Valentina AU - Agbaba, Danica AU - Vladimirov, S AU - Stanković, S PY - 2001 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/294 AB - A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis VL - 24 IS - 5-6 SP - 993 EP - 998 DO - 10.1016/S0731-7085(00)00531-8 ER -
@article{ author = "Marinković, Valentina and Agbaba, Danica and Vladimirov, S and Stanković, S", year = "2001", abstract = "A method has been developed for separation of nitrendipine and its impurities of reaction partners and side reaction products by high-performance liquid chromatographic method on a RP-ls column and detection at 238 nm. The mobile phase composition that provided an acceptable nitrendipine resolution, in large excess and possible impurities, in a short elution time, is methanol:water (70:30) and pH 3. Linearity (r greater than or equal to 0.999), reproducibility (RSD = 0.8-1.4%), determination limit (0.5 2%,) and recovery (99.8-102.3) were validated and found to be satisfactory. This method enables monitoring of the process of synthesis, as well as the choice of the synthetic design.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis", volume = "24", number = "5-6", pages = "993-998", doi = "10.1016/S0731-7085(00)00531-8" }
Marinković, V., Agbaba, D., Vladimirov, S.,& Stanković, S.. (2001). Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis. in Journal of Pharmaceutical and Biomedical Analysis Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 993-998. https://doi.org/10.1016/S0731-7085(00)00531-8
Marinković V, Agbaba D, Vladimirov S, Stanković S. Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis. in Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):993-998. doi:10.1016/S0731-7085(00)00531-8 .
Marinković, Valentina, Agbaba, Danica, Vladimirov, S, Stanković, S, "Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis" in Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):993-998, https://doi.org/10.1016/S0731-7085(00)00531-8 . .