TY  - JOUR
AU  - Ivanović, Nevena
AU  - Ilić, Tijana
AU  - Zrnić-Ćirić, Milica
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Dabetić, Nevena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4979
AB  - The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives.
AB  - Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
T2  - Arhiv za farmaciju
T1  - Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals
T1  - Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika
VL  - 73
IS  - 3
SP  - 190
EP  - 204
DO  - 10.5937/arhfarm73-44481
ER  - 

@article{
author = "Ivanović, Nevena and Ilić, Tijana and Zrnić-Ćirić, Milica and Todorović, Vanja and Đuričić, Ivana and Dabetić, Nevena",
year = "2023",
abstract = "The disposal of waste generated in the agri-food industry is one of the greatest challenges
in achieving sustainable development. Although agri-food residues are a potential source of
bioactive compounds with proven health benefits, they are largely unused and disposed of as
organic waste. The recovery of bioactive compounds from agri-food waste to obtain products
with high biological value, such as functional foods and nutraceuticals, is an idea that stems from
the concept of bioeconomy and combines environmental issues with economically viable
production. Some of the main agri-food wastes in Serbia that have the potential to be recycled
into value-added products are apple, plum, grape, tomato, and beet pomace, and oilseed cakes.
Bioactive compounds isolated from these wastes include polyphenols, fibers, essential fatty acids,
minerals, various volatiles and pigments. This article focuses on the most common food wastes
and the potential reuse of these undervalued material to produce value-added products such as
functional foods, nutraceuticals or food additives., Odlaganje otpada koji nastaje u prehrambenoj industriji jedan je od najvećih izazova u
postizanju održivog razvoja. Iako su nusproizvodi koji nastaju u prehrambenoj industriji
potencijalni izvor bioaktivnih jedinjenja sa dokazanim pozitivnim zdravstvenim efektima, oni se
uglavnom odlažu kao organski otpad. Iskorišćenje bioaktivnih jedinjenja iz ovih nusproizvoda u
cilju dobijanja proizvoda sa dodatom nutritivnom i biološkom vrednošću, kao što su funkcionalna
hrana i nutraceutici, ideja je koja proizilazi iz koncepta bioekonomije i kombinuje ekološki aspekt
sa ekonomski održivom proizvodnjom. Neki od glavnih nusproizvoda koji se generišu u Srbiji sa
potencijalom da se iskoriste u proizvodnji proizvoda sa dodatom vrednošću su trop jabuke, trop
šljive, komina grožđa, trop paradajza, uljane pogače i dr. Bioaktivna jedinjenja izolovana iz ovih
otpada uključuju polifenole, peptide, vlakna, esencijalne masne kiseline, minerale, različite
isparljive materije i pigmente. Ovaj članak se fokusira na najčešće otpade prehrambene industrije
i potencijalnu ponovnu upotrebu ovog još uvek neiskorišćenog otpadnog materijala za
proizvodnju proizvoda sa dodatom vrednošću kao što su funkcionalna hrana, nutraceutici ili
aditivi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals, Nusproizvodi agro-industrije kao izvor održivih sastojaka za proizvodnju funkcionalne hrane i nutraceutika",
volume = "73",
number = "3",
pages = "190-204",
doi = "10.5937/arhfarm73-44481"
}

Ivanović, N., Ilić, T., Zrnić-Ćirić, M., Todorović, V., Đuričić, I.,& Dabetić, N.. (2023). Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 73(3), 190-204.
https://doi.org/10.5937/arhfarm73-44481

Ivanović N, Ilić T, Zrnić-Ćirić M, Todorović V, Đuričić I, Dabetić N. Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals. in Arhiv za farmaciju. 2023;73(3):190-204.
doi:10.5937/arhfarm73-44481 .

Ivanović, Nevena, Ilić, Tijana, Zrnić-Ćirić, Milica, Todorović, Vanja, Đuričić, Ivana, Dabetić, Nevena, "Agri-food by-products as a source of sustainable ingredients for the production of functional foods and nutraceuticals" in Arhiv za farmaciju, 73, no. 3 (2023):190-204,
https://doi.org/10.5937/arhfarm73-44481 . .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Božić, Dragana
AU  - Antić-Stanković, Jelena
AU  - Šobajić, Slađana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5140
AB  - Semenke predstavljaju najvredniji deo ploda vinove loze. Polifenolna jedinjenja se primarno
koncentrišu tamo, zbog čega semenke poseduju jaku antioksidativnu aktivnost. Zahvaljujući tome,
ekstrakti semenki mogu delovati kao antimikrobni agensi. Ekstrakcija bioaktivnih jedinjenja se
obično vrši pomoću isparljivih, organskih rastvarača. Poslednjih godina, zajedno sa povećanjem
svesti o značaju zaštite životne sredine, različiti „zeleni“ rastvarači su se pojavili kao alternativa
konvencionalnim.
Ova studija je imala za cilj ispitivanje razlika između semenki različitih sorti grožđa u pogledu
njihove antimikrobne aktivnosti prema Staphylococcus aureus. Takođe je procenjen afinitet
eutektičkog rastvarača za ekstrakciju polifenola iz semenki grožđa. Kao referentni rastvarač
korišćen je etanol.
Semenke su izolovane iz pet različitih sorti crvenog grožđa koje se široko gaje u Srbiji.
Ultrazvučna ekstrakcija izvedena je korišćenjem eutektičkog rastvarača (holin hlorid:limunska
kiselina, 2:1, 30 % vode; ChCit) i 70 % etanola. Ukupan sadržaj polifenola (eng. Total Phenolic
Content; TPC) je određen Folin-Ciocalteu metodom. Antimikrobna aktivnost uzoraka je ispitivana
je na standardnom soju Staphylococcus aureus ATCC 6538 bujon-mikrodilucionim testom.
TPC vrednosti su se kretale od 91,75 do 116,71 i od 84,79 do 135,5 mg GAE/g suve mase (za
ChCit i etanolne ekstrakte, respektivno). Semenke sorte Prokupac imale su najveći sadržaj ukupnih
polifenola, bez obzira na upotrebljeni rastvarač. Vrednosti minimalnih inhibitornih koncentracija
(MIK) su se kretale između 0,04 i 0,15 mg/ml. ChCit ekstrakti su bili slični ili čak efikasniji protiv
ove Gram-pozitivne bakterije u poređenju sa etanolnim ekstraktima. Ovo bi moglo biti delimično
objašnjeno antimikrobnom aktivnošću samog rastvarača, pošto je primećeno da ChCit inhibira rast
Staphylococcus aureus (MIK=0,3 mg/ml).
Imajući u vidu da su ekstrakti pokazali znatno jaču aktivnost u odnosu na rastvarač i da su
rezultati ispitivanja antimikrobne aktivnosti bili u značajnoj korelaciji sa sadržajem polifenola,
može se zaključiti da je sinergizam između prisutnih polifenola i ChCit rezultirao snažnom
antimikrobnom aktivnošću protiv Staphylococcus aureus u ekološki prihvatljivijim ekstraktima.
PB  - Srpsko udruženje za kliničku mikrobiologiju (SUKM)
C3  - SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata
T1  - Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa
SP  - 56
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5140
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Božić, Dragana and Antić-Stanković, Jelena and Šobajić, Slađana",
year = "2023",
abstract = "Semenke predstavljaju najvredniji deo ploda vinove loze. Polifenolna jedinjenja se primarno
koncentrišu tamo, zbog čega semenke poseduju jaku antioksidativnu aktivnost. Zahvaljujući tome,
ekstrakti semenki mogu delovati kao antimikrobni agensi. Ekstrakcija bioaktivnih jedinjenja se
obično vrši pomoću isparljivih, organskih rastvarača. Poslednjih godina, zajedno sa povećanjem
svesti o značaju zaštite životne sredine, različiti „zeleni“ rastvarači su se pojavili kao alternativa
konvencionalnim.
Ova studija je imala za cilj ispitivanje razlika između semenki različitih sorti grožđa u pogledu
njihove antimikrobne aktivnosti prema Staphylococcus aureus. Takođe je procenjen afinitet
eutektičkog rastvarača za ekstrakciju polifenola iz semenki grožđa. Kao referentni rastvarač
korišćen je etanol.
Semenke su izolovane iz pet različitih sorti crvenog grožđa koje se široko gaje u Srbiji.
Ultrazvučna ekstrakcija izvedena je korišćenjem eutektičkog rastvarača (holin hlorid:limunska
kiselina, 2:1, 30 % vode; ChCit) i 70 % etanola. Ukupan sadržaj polifenola (eng. Total Phenolic
Content; TPC) je određen Folin-Ciocalteu metodom. Antimikrobna aktivnost uzoraka je ispitivana
je na standardnom soju Staphylococcus aureus ATCC 6538 bujon-mikrodilucionim testom.
TPC vrednosti su se kretale od 91,75 do 116,71 i od 84,79 do 135,5 mg GAE/g suve mase (za
ChCit i etanolne ekstrakte, respektivno). Semenke sorte Prokupac imale su najveći sadržaj ukupnih
polifenola, bez obzira na upotrebljeni rastvarač. Vrednosti minimalnih inhibitornih koncentracija
(MIK) su se kretale između 0,04 i 0,15 mg/ml. ChCit ekstrakti su bili slični ili čak efikasniji protiv
ove Gram-pozitivne bakterije u poređenju sa etanolnim ekstraktima. Ovo bi moglo biti delimično
objašnjeno antimikrobnom aktivnošću samog rastvarača, pošto je primećeno da ChCit inhibira rast
Staphylococcus aureus (MIK=0,3 mg/ml).
Imajući u vidu da su ekstrakti pokazali znatno jaču aktivnost u odnosu na rastvarač i da su
rezultati ispitivanja antimikrobne aktivnosti bili u značajnoj korelaciji sa sadržajem polifenola,
može se zaključiti da je sinergizam između prisutnih polifenola i ChCit rezultirao snažnom
antimikrobnom aktivnošću protiv Staphylococcus aureus u ekološki prihvatljivijim ekstraktima.",
publisher = "Srpsko udruženje za kliničku mikrobiologiju (SUKM)",
journal = "SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata",
title = "Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa",
pages = "56-56",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5140"
}

Dabetić, N., Todorović, V., Božić, D., Antić-Stanković, J.,& Šobajić, S.. (2023). Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa. in SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata
Srpsko udruženje za kliničku mikrobiologiju (SUKM)., 56-56.
https://hdl.handle.net/21.15107/rcub_farfar_5140

Dabetić N, Todorović V, Božić D, Antić-Stanković J, Šobajić S. Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa. in SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata. 2023;:56-56.
https://hdl.handle.net/21.15107/rcub_farfar_5140 .

Dabetić, Nevena, Todorović, Vanja, Božić, Dragana, Antić-Stanković, Jelena, Šobajić, Slađana, "Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa" in SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata (2023):56-56,
https://hdl.handle.net/21.15107/rcub_farfar_5140 .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Zrnić-Ćirić, Milica
AU  - Vidović, Bojana
AU  - Todorović, Vanja
AU  - Dabetić, Nevena
AU  - Ivanović, Nevena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5375
AB  - The immune system defends the host from many pathogen-
ic microorganisms such as viruses, bacteria, parasites and
fungi, including a large number of specific cell types, inter-
related molecules, and biological responses. Due to infec-
tions, heightened immune system activity is accompanied
by expanded metabolic activities, requiring appropriate
energy supply, precursors for biosynthesis and regulatory
molecules. Numerous vitamins and minerals play a crucial
role in supporting body’s immunity and fighting against
viral infections. Other bioactive compounds like omega-3
fatty acids, probiotics and antioxidants (alpha-lipoic acid,
quercetin) are also important in the immune response. CO-
VID-19 may develop mild symptoms to severe damage of
the respiratory epithelium followed by a cytokine storm.
Many studies show that vitamin C, vitamin D, zinc and selenium are critical in defending against SARS-CoV-2 infection.
Intestinal dysbiosis is a feature of many infectious diseases, including COVID-19, so dietary approaches to establishing a
healthy microbiota are essential for improving immune function. This paper reviews the data on the roles and potential
effectiveness of selected nutraceuticals in the prevention and treatment of COVID-19.
AB  - Imunski sistem štiti organizam od brojnih patogena (bakterija, virusa, gljivica, parazita) uključujući veliki broj specijalizovanih tipova ćelija, komunikacionih molekula i
funkcionalnih odgovora. Pojačana aktivnost imunskog si
stema usled infekcija praćena je povećanim metaboličkim
aktivnostima, što zahteva izvore energije, supstrate za biosintezu i regulatorne molekule. Brojni vitamini i minerali
imaju ključnu ulogu u podršci imunskom sistemu i smanjenju rizika od infekcija. Ostale bioaktivne komponente kao omega-3 masne kiseline, probiotici i antioksidansi (alfa-lipoinska kiselina, kvercetin) takođe su od značaja u imunološkom
odgovoru. COVID-19 karakterišu kliničke slike od blagih simptoma do teške infekcije respiratornog epitela praćene citokinskom olujom. Pokazano je da starije osobe sa hroničnim bolestima imaju smanjenu aktivnost odbrambenog sistema
i neadekvatan nutritivni status, zbog čega postoji veći rizik za pojavu fatalnih ishoda. Ispitivanja ukazuju da su vitamin
C, vitamin D, cink i selen posebno važni u odbrani od infekcije SARS-CoV-2. Disbioza creva je karakteristika mnogih zaraznih bolesti uključujući COVID-19, zato su dijetetski pristupi za uspostavljanje zdrave mikrobiote važni u poboljšanju
imunoloških funkcija. U ovom radu prikazan je pregled literature o ulozi i potencijalnoj primeni odabranih nutraceutika u
prevenciji i tretmanu COVID-19.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Nutraceuticals in prevention and management of COVID-19
T1  - Nutraceutici u prevenciji i tretmanu COVID-19
VL  - 62
IS  - 2
SP  - 7
EP  - 14
DO  - 10.5937/hraIsh2102007D
ER  - 

@article{
author = "Đuričić, Ivana and Zrnić-Ćirić, Milica and Vidović, Bojana and Todorović, Vanja and Dabetić, Nevena and Ivanović, Nevena",
year = "2021",
abstract = "The immune system defends the host from many pathogen-
ic microorganisms such as viruses, bacteria, parasites and
fungi, including a large number of specific cell types, inter-
related molecules, and biological responses. Due to infec-
tions, heightened immune system activity is accompanied
by expanded metabolic activities, requiring appropriate
energy supply, precursors for biosynthesis and regulatory
molecules. Numerous vitamins and minerals play a crucial
role in supporting body’s immunity and fighting against
viral infections. Other bioactive compounds like omega-3
fatty acids, probiotics and antioxidants (alpha-lipoic acid,
quercetin) are also important in the immune response. CO-
VID-19 may develop mild symptoms to severe damage of
the respiratory epithelium followed by a cytokine storm.
Many studies show that vitamin C, vitamin D, zinc and selenium are critical in defending against SARS-CoV-2 infection.
Intestinal dysbiosis is a feature of many infectious diseases, including COVID-19, so dietary approaches to establishing a
healthy microbiota are essential for improving immune function. This paper reviews the data on the roles and potential
effectiveness of selected nutraceuticals in the prevention and treatment of COVID-19., Imunski sistem štiti organizam od brojnih patogena (bakterija, virusa, gljivica, parazita) uključujući veliki broj specijalizovanih tipova ćelija, komunikacionih molekula i
funkcionalnih odgovora. Pojačana aktivnost imunskog si
stema usled infekcija praćena je povećanim metaboličkim
aktivnostima, što zahteva izvore energije, supstrate za biosintezu i regulatorne molekule. Brojni vitamini i minerali
imaju ključnu ulogu u podršci imunskom sistemu i smanjenju rizika od infekcija. Ostale bioaktivne komponente kao omega-3 masne kiseline, probiotici i antioksidansi (alfa-lipoinska kiselina, kvercetin) takođe su od značaja u imunološkom
odgovoru. COVID-19 karakterišu kliničke slike od blagih simptoma do teške infekcije respiratornog epitela praćene citokinskom olujom. Pokazano je da starije osobe sa hroničnim bolestima imaju smanjenu aktivnost odbrambenog sistema
i neadekvatan nutritivni status, zbog čega postoji veći rizik za pojavu fatalnih ishoda. Ispitivanja ukazuju da su vitamin
C, vitamin D, cink i selen posebno važni u odbrani od infekcije SARS-CoV-2. Disbioza creva je karakteristika mnogih zaraznih bolesti uključujući COVID-19, zato su dijetetski pristupi za uspostavljanje zdrave mikrobiote važni u poboljšanju
imunoloških funkcija. U ovom radu prikazan je pregled literature o ulozi i potencijalnoj primeni odabranih nutraceutika u
prevenciji i tretmanu COVID-19.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Nutraceuticals in prevention and management of COVID-19, Nutraceutici u prevenciji i tretmanu COVID-19",
volume = "62",
number = "2",
pages = "7-14",
doi = "10.5937/hraIsh2102007D"
}

Đuričić, I., Zrnić-Ćirić, M., Vidović, B., Todorović, V., Dabetić, N.,& Ivanović, N.. (2021). Nutraceuticals in prevention and management of COVID-19. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 62(2), 7-14.
https://doi.org/10.5937/hraIsh2102007D

Đuričić I, Zrnić-Ćirić M, Vidović B, Todorović V, Dabetić N, Ivanović N. Nutraceuticals in prevention and management of COVID-19. in Hrana i ishrana. 2021;62(2):7-14.
doi:10.5937/hraIsh2102007D .

Đuričić, Ivana, Zrnić-Ćirić, Milica, Vidović, Bojana, Todorović, Vanja, Dabetić, Nevena, Ivanović, Nevena, "Nutraceuticals in prevention and management of COVID-19" in Hrana i ishrana, 62, no. 2 (2021):7-14,
https://doi.org/10.5937/hraIsh2102007D . .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Vidović, Bojana
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5397
AB  - Grape seeds contain a wide range of phenolic compounds responsible for its health promoting
effects. Interest for grape seed utilization has increased significantly along with a growing
recognition that present biologically active compounds were not completely isolated during the
extraction process. Numerous studies have been conducted in order to achieve the best
extraction recovery. Nevertheless, there is still a question concerning the pretreatment of grape
seeds. The aim of the present study was to investigate the impact of defatting process on total
polyphenol content and antioxidant activity of grape seed extracts. For that purpose seeds were
obtained from eight different grape varieties. Extraction with 70 % ethanol was performed on
both, crude and defatted seeds (lipid fraction was removed by Soxhlet method of extraction).
Determination of total phenolic content (TPC) was done using Folin-Ciocalteu assay.
Antioxidant activity was investigated through four different tests (FRAP, CUPRAC, DPPH and
ABTS) and obtained results were combined in unique Antioxidant Composite Index (ACI). TPC
values ranged from 50.48 to 121.06 and from 38.04 to 108.17 mg GAE/g dry weight for crude
and defatted grape seed extracts, respectively. Higher phenolic content determined in extracts
obtained from crude seeds could be explained by the presence of lipophilic biologically active
compounds in non-removed lipid fraction. Discrepancies between varieties are presumably
present due to different morphological properties of seeds, environmental and agricultural
conditions. Concerning antioxidant activity, all tests were significantly correlated with TPC,
suggesting the strong contribution of phenolic compounds to this biological activity.
PB  - University of Belgrade, Belgrade, Serbia
C3  - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
T1  - Impact of defatting process on antioxidant potential of grape seeds
SP  - 34
EP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5397
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Vidović, Bojana and Šobajić, Slađana",
year = "2020",
abstract = "Grape seeds contain a wide range of phenolic compounds responsible for its health promoting
effects. Interest for grape seed utilization has increased significantly along with a growing
recognition that present biologically active compounds were not completely isolated during the
extraction process. Numerous studies have been conducted in order to achieve the best
extraction recovery. Nevertheless, there is still a question concerning the pretreatment of grape
seeds. The aim of the present study was to investigate the impact of defatting process on total
polyphenol content and antioxidant activity of grape seed extracts. For that purpose seeds were
obtained from eight different grape varieties. Extraction with 70 % ethanol was performed on
both, crude and defatted seeds (lipid fraction was removed by Soxhlet method of extraction).
Determination of total phenolic content (TPC) was done using Folin-Ciocalteu assay.
Antioxidant activity was investigated through four different tests (FRAP, CUPRAC, DPPH and
ABTS) and obtained results were combined in unique Antioxidant Composite Index (ACI). TPC
values ranged from 50.48 to 121.06 and from 38.04 to 108.17 mg GAE/g dry weight for crude
and defatted grape seed extracts, respectively. Higher phenolic content determined in extracts
obtained from crude seeds could be explained by the presence of lipophilic biologically active
compounds in non-removed lipid fraction. Discrepancies between varieties are presumably
present due to different morphological properties of seeds, environmental and agricultural
conditions. Concerning antioxidant activity, all tests were significantly correlated with TPC,
suggesting the strong contribution of phenolic compounds to this biological activity.",
publisher = "University of Belgrade, Belgrade, Serbia",
journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade",
title = "Impact of defatting process on antioxidant potential of grape seeds",
pages = "34-34",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5397"
}

Dabetić, N., Todorović, V., Vidović, B.,& Šobajić, S.. (2020). Impact of defatting process on antioxidant potential of grape seeds. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
University of Belgrade, Belgrade, Serbia., 34-34.
https://hdl.handle.net/21.15107/rcub_farfar_5397

Dabetić N, Todorović V, Vidović B, Šobajić S. Impact of defatting process on antioxidant potential of grape seeds. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:34-34.
https://hdl.handle.net/21.15107/rcub_farfar_5397 .

Dabetić, Nevena, Todorović, Vanja, Vidović, Bojana, Šobajić, Slađana, "Impact of defatting process on antioxidant potential of grape seeds" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):34-34,
https://hdl.handle.net/21.15107/rcub_farfar_5397 .

TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Panić, Manuela
AU  - Radojčić Redovniković, Ivana
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3638
AB  - In the past few years, research efforts have focused on plant exploitation for deriving some valuable compounds. Extraction has been usually performed using petrochemical and volatile organic solvents, but nowadays, increased recognition of environmental pollution has prompted the utilization of green solvents as alternatives. Therefore, the aim of the present study was to exploit deep eutectic solvents (DES) (choline chloride: citric acid and choline chloride: glucose) as solvents for extracting valuable phenolic antioxidants from grapes. Investigation was conducted on ten grape varieties, observing seeds and skin as different matrix. Total polyphenol content (TPC) was determined by Folin-Ciocalteu spectrophotometric microassay. Antioxidant activity was investigated using four different tests and results were combined in a unique Antioxidant Composite Index (ACI) to reveal comprehensive information about this biological activity. Polyphenol compounds were identified and quantified with the aim of HPLC-diode array detector (DAD). Overall results support that DES (particularly choline chloride: citric acid) were comparable to conventional solvent, and in most cases even outperformed acidified aqueous ethanol (concerning extraction efficiency and antioxidant activity). Regardless of varietal distinctions, grape seeds have higher antioxidant capacity compared to grape skin, and such findings are according to their phenol compound concentrations.
PB  - MDPI AG
T2  - Applied Sciences (Switzerland)
T1  - Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin
VL  - 10
IS  - 14
DO  - 10.3390/app10144830
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Panić, Manuela and Radojčić Redovniković, Ivana and Šobajić, Slađana",
year = "2020",
abstract = "In the past few years, research efforts have focused on plant exploitation for deriving some valuable compounds. Extraction has been usually performed using petrochemical and volatile organic solvents, but nowadays, increased recognition of environmental pollution has prompted the utilization of green solvents as alternatives. Therefore, the aim of the present study was to exploit deep eutectic solvents (DES) (choline chloride: citric acid and choline chloride: glucose) as solvents for extracting valuable phenolic antioxidants from grapes. Investigation was conducted on ten grape varieties, observing seeds and skin as different matrix. Total polyphenol content (TPC) was determined by Folin-Ciocalteu spectrophotometric microassay. Antioxidant activity was investigated using four different tests and results were combined in a unique Antioxidant Composite Index (ACI) to reveal comprehensive information about this biological activity. Polyphenol compounds were identified and quantified with the aim of HPLC-diode array detector (DAD). Overall results support that DES (particularly choline chloride: citric acid) were comparable to conventional solvent, and in most cases even outperformed acidified aqueous ethanol (concerning extraction efficiency and antioxidant activity). Regardless of varietal distinctions, grape seeds have higher antioxidant capacity compared to grape skin, and such findings are according to their phenol compound concentrations.",
publisher = "MDPI AG",
journal = "Applied Sciences (Switzerland)",
title = "Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin",
volume = "10",
number = "14",
doi = "10.3390/app10144830"
}

Dabetić, N., Todorović, V., Panić, M., Radojčić Redovniković, I.,& Šobajić, S.. (2020). Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin. in Applied Sciences (Switzerland)
MDPI AG., 10(14).
https://doi.org/10.3390/app10144830

Dabetić N, Todorović V, Panić M, Radojčić Redovniković I, Šobajić S. Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin. in Applied Sciences (Switzerland). 2020;10(14).
doi:10.3390/app10144830 .

Dabetić, Nevena, Todorović, Vanja, Panić, Manuela, Radojčić Redovniković, Ivana, Šobajić, Slađana, "Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin" in Applied Sciences (Switzerland), 10, no. 14 (2020),
https://doi.org/10.3390/app10144830 . .

TY  - JOUR
AU  - Zrnić-Ćirić, Milica
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Đuriš, Jelena
AU  - Vidović, Bojana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3628
AB  - Due to the presence of numerous bioactive compounds, including polysaccharides and polyphenols, mushroom-based food supplements are claimed to have many beneficial health effects. Despite their popularity, concerns have been raised in recent years over the quality of mushroom products, particularly regarding their non-standardized chemical composition. In this study, the β-glucan and total phenolic contents, as well as the antioxidant potential of mushroom-derived supplements available on the Serbian market were analyzed. The obtained results, revealing considerable differences in β-glucan and total polyphenol contents among these products, reflect variations in mushroom species, forms and recommended dosing regimens. A correlation between the total phenolic content and antioxidant activity was observed. The presence of other active ingredients, such as vitamin C, has contributed to antioxidant variability among the analyzed products. The obtained results indicate the need for the standardization of mushroom-derived food supplements to ensure their claiming effects.
AB  - ANALYSIS AND ANTIOXIDANT ACTIVITIES OF MUSHROOM BASED-DIETARY SUPPLEMENTS 449
ИЗВОД АНАЛИЗА САДРЖАЈА

БЕТА-ГЛУКАНА И АНТИОКСИДАТИВНА АКТИВНОСТ У ДОДАЦИМА ИСХРАНИ НА БАЗИ ГЉИВА 
МИЛИЦА ЗРНИЋЋИРИЋ1, НЕВЕНА ДАБЕТИЋ1, ВАЊА ТОДОРОВИЋ1, ЈЕЛЕНА ЂУРИШ2 и БОЈАНА ВИДОВИЋ11 Универзитет у Београду, Фармацеутскифакултет, Катедра за Броматологију, Београд Универзитет у Београду, Фармацеутски факултет, Катедра за Фармацеутску технологију и козметологију, Београд. Због присуства бројних биоактивних састојака, укључујући полисахариде и поли-феноле, додаци исхрани на бази гљива имају бројне позитивне здравствене ефекте. Поред популарности, последњих година се велика пажња посвећује и квалитету производа од гљива, посебно у погледу њиховог не стандардизованог хемијског састава. У овом раду анализиранје садржајβ-глукана и укупних полифенола, као и антиоксидативни потенцијал додатака исхрани на бази гљива који су доступни на тржишту Србије. Добијени резултати су показали велике разлике у садржају β-глукана и укупних полифенола што се може објаснити различитим врстама гљива, облицима и режимима дозирања. Уочена је корелација између укупног садржаја полифенола и антиоксидативне активности. Присуство других биолошки активних састојака, као што је витамин Ц, допринело је варијабилности антиоксидантне активности између анализираних производа. Добијени резултати указују на потребу за стандардизацијом дoдатака исхрани на бази гљива, како би се осигурао њихов ефекат.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Beta-glucan content and antioxidant activities of mushroom-derived food supplements
VL  - 85
IS  - 4
SP  - 439
EP  - 451
DO  - 10.2298/JSC190701121Z
ER  - 

@article{
author = "Zrnić-Ćirić, Milica and Dabetić, Nevena and Todorović, Vanja and Đuriš, Jelena and Vidović, Bojana",
year = "2020",
abstract = "Due to the presence of numerous bioactive compounds, including polysaccharides and polyphenols, mushroom-based food supplements are claimed to have many beneficial health effects. Despite their popularity, concerns have been raised in recent years over the quality of mushroom products, particularly regarding their non-standardized chemical composition. In this study, the β-glucan and total phenolic contents, as well as the antioxidant potential of mushroom-derived supplements available on the Serbian market were analyzed. The obtained results, revealing considerable differences in β-glucan and total polyphenol contents among these products, reflect variations in mushroom species, forms and recommended dosing regimens. A correlation between the total phenolic content and antioxidant activity was observed. The presence of other active ingredients, such as vitamin C, has contributed to antioxidant variability among the analyzed products. The obtained results indicate the need for the standardization of mushroom-derived food supplements to ensure their claiming effects., ANALYSIS AND ANTIOXIDANT ACTIVITIES OF MUSHROOM BASED-DIETARY SUPPLEMENTS 449
ИЗВОД АНАЛИЗА САДРЖАЈА

БЕТА-ГЛУКАНА И АНТИОКСИДАТИВНА АКТИВНОСТ У ДОДАЦИМА ИСХРАНИ НА БАЗИ ГЉИВА 
МИЛИЦА ЗРНИЋЋИРИЋ1, НЕВЕНА ДАБЕТИЋ1, ВАЊА ТОДОРОВИЋ1, ЈЕЛЕНА ЂУРИШ2 и БОЈАНА ВИДОВИЋ11 Универзитет у Београду, Фармацеутскифакултет, Катедра за Броматологију, Београд Универзитет у Београду, Фармацеутски факултет, Катедра за Фармацеутску технологију и козметологију, Београд. Због присуства бројних биоактивних састојака, укључујући полисахариде и поли-феноле, додаци исхрани на бази гљива имају бројне позитивне здравствене ефекте. Поред популарности, последњих година се велика пажња посвећује и квалитету производа од гљива, посебно у погледу њиховог не стандардизованог хемијског састава. У овом раду анализиранје садржајβ-глукана и укупних полифенола, као и антиоксидативни потенцијал додатака исхрани на бази гљива који су доступни на тржишту Србије. Добијени резултати су показали велике разлике у садржају β-глукана и укупних полифенола што се може објаснити различитим врстама гљива, облицима и режимима дозирања. Уочена је корелација између укупног садржаја полифенола и антиоксидативне активности. Присуство других биолошки активних састојака, као што је витамин Ц, допринело је варијабилности антиоксидантне активности између анализираних производа. Добијени резултати указују на потребу за стандардизацијом дoдатака исхрани на бази гљива, како би се осигурао њихов ефекат.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Beta-glucan content and antioxidant activities of mushroom-derived food supplements",
volume = "85",
number = "4",
pages = "439-451",
doi = "10.2298/JSC190701121Z"
}

Zrnić-Ćirić, M., Dabetić, N., Todorović, V., Đuriš, J.,& Vidović, B.. (2020). Beta-glucan content and antioxidant activities of mushroom-derived food supplements. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 85(4), 439-451.
https://doi.org/10.2298/JSC190701121Z

Zrnić-Ćirić M, Dabetić N, Todorović V, Đuriš J, Vidović B. Beta-glucan content and antioxidant activities of mushroom-derived food supplements. in Journal of the Serbian Chemical Society. 2020;85(4):439-451.
doi:10.2298/JSC190701121Z .

Zrnić-Ćirić, Milica, Dabetić, Nevena, Todorović, Vanja, Đuriš, Jelena, Vidović, Bojana, "Beta-glucan content and antioxidant activities of mushroom-derived food supplements" in Journal of the Serbian Chemical Society, 85, no. 4 (2020):439-451,
https://doi.org/10.2298/JSC190701121Z . .

TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Antić-Stanković, Jelena
AU  - Bašić, Zorica N.
AU  - Vujović, Dragan S.
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3608
AB  - The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.
PB  - Wiley-VCH Verlag
T2  - European Journal of Lipid Science and Technology
T1  - Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment
VL  - 122
IS  - 6
DO  - DOI: 10.1002/ejlt.201900447
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Đuričić, Ivana and Antić-Stanković, Jelena and Bašić, Zorica N. and Vujović, Dragan S. and Šobajić, Slađana",
year = "2020",
abstract = "The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.",
publisher = "Wiley-VCH Verlag",
journal = "European Journal of Lipid Science and Technology",
title = "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment",
volume = "122",
number = "6",
doi = "DOI: 10.1002/ejlt.201900447"
}

Dabetić, N., Todorović, V., Đuričić, I., Antić-Stanković, J., Bašić, Z. N., Vujović, D. S.,& Šobajić, S.. (2020). Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology
Wiley-VCH Verlag., 122(6).
https://doi.org/DOI: 10.1002/ejlt.201900447

Dabetić N, Todorović V, Đuričić I, Antić-Stanković J, Bašić ZN, Vujović DS, Šobajić S. Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology. 2020;122(6).
doi:DOI: 10.1002/ejlt.201900447 .

Dabetić, Nevena, Todorović, Vanja, Đuričić, Ivana, Antić-Stanković, Jelena, Bašić, Zorica N., Vujović, Dragan S., Šobajić, Slađana, "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment" in European Journal of Lipid Science and Technology, 122, no. 6 (2020),
https://doi.org/DOI: 10.1002/ejlt.201900447 . .