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Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease
(John Wiley and Sons Ltd, 2020)
Rationale: Changes in lipid composition might be associated with the onset and progression of various neurodegenerative diseases. Herein, we investigated the changes in the plasma phosphatidylcholine (PC)/lysophosphatidylcholine ...
Healthcare associated Clostridioides difficile infection in adult surgical and medical patients hospitalized in tertiary hospital in Belgrade, Serbia: a seven years prospective cohort study
(Taylor & Francis, 2020)
Introduction: Clostridioides difficile (C. difficile) infection (CDI) is one of the most common healthcare-associated (HA) infections in contemporary medicine. The risk factors (RFs) for HA CDI in medical and surgical ...
Biological evaluation of oil-in-water microemulsions as carriers of benzothiophene analogues for dermal applications
(MDPI AG, 2021)
During the last decade, many studies have been reported on the design and formulation of novel drug delivery systems proposed for dermal or transdermal administration. The efforts focus on the development of biocompatible ...
Sex as a confounding factor in the effects of ageing on rat lymph node t cell compartment
(Elsevier Inc., 2020)
The study examined the influence of sex on the alterations occurring with ageing in rat lymph node (LN) T cell compartment. In female and male rats the decrease in LN T cell counts was followed by a shift in CD4+/CD8+ T ...
Mimicking of phase I metabolism reactions of molindone by HLM and photocatalytic methods with the use of UHPLC-MS/MS
(MDPI AG, 2020)
Establishing the metabolism pathway of the drug undergoing the hepatic biotransformation pathway is one of the most important aspects in the preclinical discovery process since the presence of toxic or reactive metabolites ...
Compensatory Neuroprotective Response of Thioredoxin Reductase against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation
(MDPI, 2020)
Cortical theta burst stimulation (TBS) structured as intermittent (iTBS) and continuous (cTBS)could prevent the progression of the experimental autoimmune encephalomyelitis (EAE). The interplayof brain antioxidant defense ...
Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands
(Wiley-VCH Verlag, 2021)
Dopamine is an important neurotransmitter in the human brain and its altered concentrations can lead to various neurological diseases. We studied the binding of novel compounds at the dopamine D2 (D2R) and D3 (D3R) receptor ...
Total leukocyte count, leukocyte subsets and their indexes in relation to cardiovascular risk in adolescent population
(Verduci Editore s.r.l, 2021)
OBJECTIVE: No studies investigated total leukocytes, their subpopulations and novel indexes based on different ratios of leukocyte subsets concerning cardiovascular risk (CV) risk in late adolescents. Therefore, the aim ...
Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data
(MDPI AG, 2020)
Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation ...
Indirect reference intervals for haematological parameters in capillary blood of pre-school children
(Zagreb : Hrvatsko drustvo medicinskih biokemičara, 2021)
Introduction: Indirect estimation of reference intervals (RIs) is straightforward and inexpensive procedure for determination of intra-laboratory RIs. We applied the indirect approach to assess RIs for haematological ...