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Multicriteria optimization methodology in development of HPLC separation of mycophenolic acid and mycophenolic acid glucuronide in human urine and plasma
(Elsevier Science BV, Amsterdam, 2009)
Multicriteria optimization methodology was applied for development of isocratic reversed-phased HPLC method for simultaneous determination of mycophenolic acid (MPA) and mycophenolic acid glucuronide (MPAG) in human urine ...
Determination of paracetamol in pure and pharmaceutical dosage forms by pulse perturbation technique
(Elsevier Science BV, Amsterdam, 2006)
A new procedure for kinetic determination of paracetamol in pharmaceuticals is proposed. The method is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system being in a stable ...
Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 ...
Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically ...
Trace elements analysis of Echinacea purpurea - herbal medicinal
(Elsevier Science BV, Amsterdam, 2003)
Elemental composition of Echinacea purpurea (Asteracae), grown in Serbia under strongly controlled conditions, has been studied. To distinguish elemental patterns of different parts of the plant, the content of Zn, Fe, Cu, ...
Photochemical degradation of solid-state nisoldipine monitored by HPLC
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times ...
Acid-base equilibria and solubility of loratadine and desloratadine in water and micellar media
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
Acid-base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton-Robinson's buffer at 25 degrees C. Acidity constant of ...
Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
(Elsevier Science BV, Amsterdam, 2004)
In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), ...
Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity
(Elsevier Science BV, Amsterdam, 2004)
Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylun ...
Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method
(Elsevier Science BV, Amsterdam, 2009)
The objective of the present study was to report the stability profile of novel antimigrain drug Eletriptan hydrobromide based on the information obtained from forced degradation studies. The drug was subjected to acid ...