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Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus
(Elsevier B.V., 2022)
Positive allosteric modulators (PAMs) of α5GABAA receptors (α5GABAARs) are emerging as potential therapeutics for a range of neuropsychiatric disorders. However, their role in memory processing of healthy animals is not ...
Toward the synthesis of incargranine B and seneciobipyrrolidine. Synthesis of octahydro-dipyrroloquinoline skeleton via dipolar cycloaddition/amination sequence
(Wiley, HeteroCorporation, 2021)
Octahydro-dipyrroloquinoline skeleton is the building component of a very few naturally occurring compounds. Nevertheless, these natural products have been attractive synthetic targets, and their study commanded development ...
Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population
(John Wiley and Sons Inc, 2022)
Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic ...
Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL
(MDPI, 2022)
Atherosclerosis is responsible for large cardiovascular mortality in many countries globally. It has been shown over the last decades that the reduction of atherosclerotic progression is a critical factor for preventing ...
Spatial distribution of multielements including lanthanides in sediments of Iron Gate I Reservoir in the Danube River
(Springer Science and Business Media Deutschland GmbH, 2021)
Recent studies show that lanthanides (Ln) are becoming emerging pollutants due to their wide application in new technologies,but their environmental fate, transport, and possible accumulation are still relatively unknown. ...
Binuclear Co(II) complexes with macrocycle and carboxylato ligands: structure, cytotoxicity and thermal behavior
(Elsevier B.V., 2021)
In vitro cytotoxic evaluation, formation constants and thermal stability of four mixed-ligand Co(II) complexes with tpmc = N,N',N",N'"-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane and carboxylate/dicarboxylate ...
The Influences of Climatic and Lithological Factors on Weathering of Sediments in Humid Badland Areas
(Frontiers Media S.A., 2022)
Climate variables including temperature, rainfall intensity, rainfall acidity, and lithological properties are among the most important factors affecting rock weathering. However, the relative contribution of these four ...
C-protein α-antigen modulates the lantibiotic thusin resistance in Streptococcus agalactiae
(Springer Nature, 2021)
Screening for producers of potent antimicrobial peptides, resulted in the isolation of Bacillus cereus BGNM1 with strong antimicrobial activity against Listeria monocytogenes. Genome sequence analysis revealed that BGNM1 ...
In vitro colistin susceptibility of pandrug-resistant Ac. baumannii is restored in the presence of selenium nanoparticles
(John Wiley and Sons Inc, 2022)
Aims: To investigate the synergistic activity of colistin and selenium nanoparticles (SeNPs) against pandrug-resistant (PDR) Ac. baumannii. Methods and Results: Chequerboard and time-kill assays were employed to ex- plore ...
Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus
(Verduci Editore srl, 2022)
OBJECTIVE: To our knowledge, there are no studies that investigated the relationship between diabetes mellitus type 2 (T2D) and some novel indexes, such as monocyte/granulocyte to lymphocyte ratio (M/GLR), derived neutrophil ...