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Development and validation of liquid chromatography method for the separation of valdecoxib and its SC-77852 impurity
(Taylor & Francis Inc, Philadelphia, 2006)
A reversed-phase liquid chromatography method has been developed for the separation of valdecoxib and impurity SC-77852. The best results were achieved using a mobile phase-methanol: 1% water solution TEA (52 : 48 v/v), ...
Chemometrical approach in fosinopril-sodium and its degradation product fosinoprilat analysis
(Springer Heidelberg, Heidelberg, 2004)
In this paper the experimental design has been applied to define the optimum chromatographic conditions for the separation of Fosinopril sodium and its degradation product, fosinoprilat. Fosinopril is a prodrug and after ...
Statistical optimization applied to simultaneous determination of maprotiline, desipramine, and moclobemide by capillary zone electrophoresis
(Springer Wien, Wien, 2008)
A method of Capillary Zone Electrophoresis (CZE) for separation of three most-frequently prescribed antidepressants in the market: maprotiline, desipramine, and moclobemide was developed. The proposed method is fully ...
Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers
(Vieweg, Wiesbaden, 2007)
An HPLC method has been developed for the separation of valdecoxib and a degradation product consisting of alpha and beta-N-lactosyl sulfonamide, i.e. alpha and beta anomers (SC-77852). Best results were achieved with a ...
Central Composite Design with/without Artificial Neural Networks in Microemulsion Liquid Chromatography Separation Robustness Testing
(Slovensko Kemijsko Drustvo, Ljubljana, 2009)
In past few years, for overcoming some analytical problems in liquid chromatography, the microemulsion as eluent was employed. Due to the strict regulatory requirements, robustness testing became important especially when ...
Using experimental design in optimisation of VIS spektrophotometric method of investigation feroglicin sulfate in Orferon retard tablets / Primena eksperimentalnog dizajna u optimizaciji VIS spektrofotometrijske metode za određivanje feroglicin sulfata u Orferon retard tabletama
(Savez farmaceutskih udruženja Srbije, Beograd, 2004)
Iron preparations are used in the treatment or prophylaxis of sideropenic anemia developed due to insuficiency of iron in the body. They can be used orally (tablets, capsules, suspensiones, wines ) and parenterally. The ...
Experimental design in reversed-phase high-performance liquid chromatographic analysis of imatinib mesylate and its impurity
(Elsevier Science BV, Amsterdam, 2004)
For the determination of the optimal RP-HPLC chromatographic conditions for the separation of imatinib mesylate and its impurity STI 509-00 experimental design 2(4) was applied. All the factors that affect imatinib ...
An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media
(Taylor & Francis Ltd, Abingdon, 2006)
The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release ...
LC determination of lercanidipine and its impurities using DryLab software and experimental design procedures
(Vieweg, Wiesbaden, 2008)
The main objective in all optimization procedures is to define the most appropriate conditions for rapid, sensitive, precise, and reproducible analysis, as economically as possible. Experimental design and DryLab optimization ...
RP HPLC investigation of some diuretics using exsperimental design / RP HPLC ispitivanje pojedinih diuretika primenom eksperimentalnog dizajna
(Savez farmaceutskih udruženja Srbije, Beograd, 2002)
Diuretics are chemicals that increase the rate of urine formation. This pharmacologic property has led to the use of diuretics in the treatment of edematous conditions resulting from a variety of causes (e.g. congestive ...