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Opioids and adjuvant analgesics in current treating of pain / Opioidni i adjuvantni analgetici u savremenom lečenju bola
(Savez farmaceutskih udruženja Srbije, Beograd, 2019)
Morphine, as a paradigm of opioids, is 'gold standard' in treating severe pain, to which all other drugs are compared. However, abuse and respiratory depression potentials have resulted in 'opiophobia' among health ...
Application of in vitro PAMPA technique and in silico computational methods for blood-brain barrier permeability prediction of novel CNS drug candidates
(Elsevier B.V., 2022)
Permeability assessment of small molecules through the blood-brain barrier (BBB) plays a significant role in the development of effective central nervous system (CNS) drug candidates. Since in vivo methods for BBB permeability ...
Sticanje i pozivanje prostorne memorije kod potomstva ženki pacova izloženih lipopolisaharidom izazvanom zapaljenju tokom trudnoće
(Univerzitet u Beogradu - Medicinski fakultet, Beograd, 2015)
Introduction: Animal models enable the investigation of association between maternal inflammation during pregnancy and different neuropsychiatric disorders in offspring, which has been reported in epidemiological studies. ...
CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry
(Frontiers Media S.A., 2021)
Genetic differences in cytochrome P450 (CYP)-mediated metabolism have been known for several decades. The clinically most important polymorphic CYP enzyme is CYP2D6, which plays a key role in the metabolism of many ...
Potentially Inappropriate Prescribing in Older Primary Care Patients
(Public Library Science, San Francisco, 2014)
Objectives: The aim of the study was to determine the rate of Potentially Inappropriate Medicines (PIM) and Potential Prescription Omissions (PPO) according to Screening Tool of Older Person's potentially inappropriate ...
Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): Lessons from research on rats with distinct age and strain
(Termedia Publishing House Ltd., 2019)
Natural killer (NK) cells, influencing dendritic cell (DC)-mediated CD4+ lymphocyte priming in draining lymph nodes (dLNs) and controlling spinal cord (SC) infiltration with encephalitogenic CD4+T lymphocytes, modulate EAE ...
Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells
(Hindawi Publishing Corporation, 2015)
Trametes species have been used for thousands of years in traditional and conventional medicine for the treatment of various types of diseases. The goal was to evaluate possible antigenotoxic effects of mycelium and ...
Aspects of DryLab® software application in chromatography methods optimization and robustness testing / Aspekti primene DryLab® softvera u optimizaciji i proceni robusnosti hromatografskih metoda
(Savez farmaceutskih udruženja Srbije, Beograd, 2014)
In this review article, aspects of DryLab® software application in liquid chromatography are given. Literature survey shows wide application of software for chromatography method development, optimization, as well as for ...
Development of Karl Fischer titration method using Duality by Design concept / Razvoj metode titracije po Karl Fišeru primenom tzv. Quality by Design koncepta
(Savez hemijskih inženjera, Beograd, 2012)
Modern trends in drug quality control are moving toward incorporating quality into the method during its development. That course is in accordance with Quality by Design (QbD) concept defined by ICH Q 8 (R2) guideline. ...
Strategy of IFCC standardization and use of cardiac markers in acute coronary syndromes / Strategija IFCC standardizacije i primene srčanih markera u akutnom koronarnom sindromu
(Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd, 2003)
Although the use of troponin to diagnose acute myocardial infarction (AMI) has been previously proposed, the Committee on Standardization of Markers of Cardiac Damage (C-SMCD) of the International Federation of Clinical ...