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Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease
(Clin Lab Publ, Heidelberg, 2011)
Background: Beta-trace protein (BTP) was found to be increased in the serum and urine of patients with renal diseases. The aim of this study was to compare the urinary levels of beta-trace protein with levels of other ...
An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen
(Pharmaceutical Soc Korea, Seoul, 2011)
In the present work we investigated the feasibility of chitosan treated Ca-alginate microparticles for delivery of naproxen in lower parts of GIT and evaluated influence of formulation factors on their physicochemical ...
Propranolol Impairs Primary Immune Responses in Rat Experimental Autoimmune Encephalomyelitis
(S. Karger AG, 2019)
Objective: We examined the effect of β-adrenoceptor (AR) blockade in the preclinical phase of experimental autoimmune encephalomyelitis (EAE), the most commonly used model of multiple sclerosis, on the development of primary ...
A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products
(Univ Silesia, Inst Chemistry, Katowice, 2007)
A simple, conventional TLC method has been established for separation of clopidogrel and its hydrolytic product SR 26334, the main impurity in clopidogrel. Use of aluminium. foil-backed silica gel 60F(254) plates with ...
The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain
(General Physiol And Biophysics, Bratislava, 2009)
The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats ...
Synthesis of 4-Aryl-2-aminopyridine Derivatives and Related Compounds
(Taylor & Francis Inc, Philadelphia, 2009)
A short, efficient, and high-yielding synthesis of 4-aryl-2-aminopyridine derivatives has been developed. The route employs two palladium-catalyzed processes, the Suzuki reaction and the Buchwald-Hartwig amination, as the ...
Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication
(John Libbey Eurotext Ltd, Montrouge, 2010)
One of the important mechanisms of cadmium (Cd) toxicity is its interactions with bioelements, including magnesium (Mg). Exposure to Cd leads to disturbances in Mg metabolism in the organism, while Mg supplementation has ...
Chemometrically Assisted Development and Validation of LC for Simultaneous Determination of Carbamazepine and Its Impurities Iminostilbene and Iminodibenzyl in Solid Dosage Form
(Springer Heidelberg, Heidelberg, 2009)
A chemometrical approach was applied to develop a reversed-phase liquid chromatographic method for simultaneous determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in solid dosage form. According ...
Assessment of Liquid Chromatographic Method Robustness by Use of Plackett-Burman Design
(Akademiai Kiado Zrt, Budapest, 2010)
Robustness testing is an important part of method validation. Many ideas on robustness testing can be found in the literature, but the most useful approach is application of experimental design. In the work discussed in ...
Effects of Rosiglitazone on Fasting and Postprandial Low- and High-Density Lipoproteins Size and Subclasses in Type 2 Diabetes
(Sage Publications Inc, Thousand Oaks, 2010)
Rosiglitazone may increase cardiovascular risk in patients with type 2 diabetes. Yet, its effects on atherogenic dyslipidemia are still not fully elucidated. In a prospective open-label study rosiglitazone (4 mg/day for ...