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Design of Experiments in Optimization and Validation of a Hydrophilic Interaction Liquid Chromatography Method for Determination of Amlodipine Besylate and Bisoprolol Fumarate
(Taylor & Francis Inc, Philadelphia, 2015)
In this paper chemometrically-assisted optimization and validation of hydrophilic interaction liquid chromatographic (HILIC) method for the quantitative analysis of amlodipine besylate (AB) and bisoprolol fumarate (BF) in ...
HPLC evaluation of solvolysis of a novel ester fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonide
(Taylor & Francis Inc, Philadelphia, 2011)
In this study the solvolysis of novel fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonide was analyzed in order to evaluate this process as an in vitro model for prodrug activation. The solvolysis ...
Impurity profiling of mycophenolate mofetil with the assisstance of desirability function in method development
(Taylor & Francis Inc, Philadelphia, 2011)
Multicriteria decision making methodology in combination with experimental design has been applied for optimization of stability-indicating LC/DAD method of Mycophenolate mofetil and its degradation products. Via fractional ...
Estimation of lipophilicity and retention behavior of some alpha adrenergic and imidazoline receptor ligands using rp-tlc
(Taylor & Francis Inc, Philadelphia, 2014)
The chromatographic behavior of 16 alpha adrenergic and imidazoline receptor ligands has been studied by reversed-phase thin-layer chromatography (RP-TLC) on RP-18 and CN stationary phases. Retention constant R-M(0) was ...
Chromatographic and computational lipophilicity assessment of novel antibiofilm agents
(Taylor & Francis Inc., 2020)
In this study, lipophilicity of five newly designed molecules with antibiofilm properties was estimated
for the first time. The overall goal of lipophilicity evaluation in lead generation phase is to
decrease the ...
Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology
(Taylor & Francis Inc, Philadelphia, 2015)
A simple and reliable new HPLC method with UV detection has been developed and validated for simultaneous determination of mitotane and its two metabolites DDA and DDE. Method development was carried out utilizing systematical ...
Optimization of TLC method for separation and determination of ziprasidone and its impurities
(Taylor & Francis Inc, Philadelphia, 2016)
A thin-layer chromatographic method for simultaneous determination of ziprasidone and its main impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated ...
Investigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columns
(Taylor & Francis Inc, Philadelphia, 2018)
Using theoretical models, retention mechanisms of amlodipine besilate and its impurities D, E, and F were tested, as well as bisoprolol fumarate and its impurities A, C, K, and L. Appropriate theoretical retention models ...
Identification of the factors affecting the retention of weak acid solutes in hybrid micellar systems with cetyltrimethylammonium bromide
(Taylor & Francis Inc, Philadelphia, 2019)
Retention behavior of ionized and unionized forms of ten weak acid solutes was investigated in hybrid micellar systems with varying cetyltrimethylammonium bromide concentrations (CTAB), acetonitrile (ACN) content and mobile ...