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Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies
(Newlands Press, 2022)
Post-translational modifications of histones constitute a dynamic process impacting gene expression. A well-studied modification is lysine methylation. Among the lysine histone methyltransferases, DOT1L is implicated in ...
Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL
(MDPI, 2022)
Compelling evidence supports the causative link between increased levels of low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) development. For that reason, the principal aim of ...
Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus
(Elsevier B.V., 2022)
Positive allosteric modulators (PAMs) of α5GABAA receptors (α5GABAARs) are emerging as potential therapeutics for a range of neuropsychiatric disorders. However, their role in memory processing of healthy animals is not ...
Estimation of lipophilicity and design of new 17β-carboxamide glucocorticoids using RP-HPLC and quantitative structure-retention relationships analysis
(Akademiai Kiado ZRt., 2022)
Eight 17b-carboxamide glucocorticoids with local anti-inflammatory activity were selected and their retention behavior tested in six RP-HPLC systems (I–VI). logkw, a, and 40 parameters were calculated and correlation with ...
White blood cell count, its subsets, and their indexes in type 2 diabetes mellitus / Ukupan broj leukocita, diferencijalna krvna slika i njihovi indeksi u diabetes mellitus-u tip 2
(Beograd : Savez farmaceutskih udruženja Srbije, 2022)
Due to the increased prevalence of obesity-related complications, especially type 2 diabetes
mellitus (DM2), great attention has been paid to the variety of adipokines and cytokines, i.e.
biomarkers, which are secreted ...
New azamacrocyclic binuclear Cu(II) aminocarboxylate complexes: Structural, magnetic, spectral and antiproliferative studies
(Elsevier B.V., 2022)
New cationic complexes of Cu(II) with bridged aminocarboxylates: glycine and alanine, as well as octaazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), with general ...
B-cell response to seasonal influenza vaccine in mice is amenable to pharmacological modulation through β-adrenoceptor
(Elsevier Inc., 2022)
Aims: Given that deprivation of noradrenaline acting on lymphocytes through β-adrenoceptor influences anti- body response, the effects of propranolol treatment beginning two days before immunization with quadrivalent ...
Biomarkers of aging-associated chronic inflammation as a prognostic factor for human longevity / Biomarkeri hronične inflamacije povezane sa starenjem kao prediktora dužine života
(Beograd : Savez farmaceutskih udruženja Srbije, 2022)
It has been well-established that age-associated low-grade chronic inflammation
contributes to the development of a spectrum of chronic diseases, including diabetes mellitus,
ischemic heart disease, stroke, cancer, chronic ...
Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide
(MDPI, 2022)
The susceptibility of the carbonyl group towards nucleophilic attack affords the construction of various organic compounds. Thus, investigations of carbonyl activation applying greener methodologies are highly important. ...
Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation
(MDPI, 2022)
Isoform-selective histone deacetylase (HDAC) inhibition is promoted as a rational strategy to develop safer anti-cancer drugs compared to non-selective HDAC inhibitors. Despite this presumed benefit, considerably more ...