Претраживање
Приказ резултата 1-5 од 5
The differential role of alpha(1)- and alpha(5)-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats
(Oxford Univ Press, Oxford, 2009)
The clinical use of benzodiazepines (BZs) is hampered by sedation and cognitive deterioration. Although genetic and pharmacological studies suggest that alpha(1)- and alpha(5)-containing GABA(A) receptors mediate and/or ...
Hypolocomotor activity of DIAZEPAM in wistar rats is mediated by Gabaa receptors containing the Alphal, but not the Alpha5 subunit
(Cambridge Univ Press, New York, 2008)
Non-selective and a(5) subunit-selective negative modulators of GABA(A) receptors in a single-day morris water maze task in rats
(Oxford Univ Press, Oxford, 2012)
Objective : It is well known that benzodiazepine binding site ligands
influence learning and memory and that the a5 subunit is significantly
involved in cognition enhancement mediated by the negative modu-
lation of ...
Beta CCT as well as flumazenil prevent the diazepam withdrawal-induced anxiety in the elevated plus maze in rats
(Oxford Univ Press, Oxford, 2012)
Objective : Despite a half century of clinical use and the recognized
potential of benzodiazepine dependence, the mechanisms under-
lying benzodiazepine withdrawal remain insufficiently understood.
The aim of the present ...
The influence of an a5GABAA selective agonist XLi356 on rats' performance in morris water maze
(Oxford Univ Press, Oxford, 2012)
Objective : The impairing effects of diazepam in Morris water maze
(MWM) could be partially antagonized with co-administration of an
a5 subunit selective antagonist XLi093 (Savic ́ et al., 2009). In order
to further ...