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Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)
(Frontiers Media Sa, Lausanne, 2015)
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on ...
Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?
(Nature Publishing Group, London, 2008)
Classical benzodiazepines (BZs) exert anxiolytic, sedative, hypnotic, muscle relaxant, anticonvulsive, and amnesic effects through potentiation of neurotransmission at GABA(A) receptors containing alpha(1), alpha(2), ...
The role of communication and health literacy on patient safety in public pharmacies in the Republic of Srpska
(Elsevier Science Inc, 2013)
Health literacy is the skill (social and cognitive) that determines the motivation
and ability of the person to receive, understand and use information in order
to improve and maintain good health. Communication between ...
Salivary IgA response to astaxanthin supplementation in young soccer players
(Cambridge Univ Press, Cambridge, 2013)
Habitual exercise at an intense level can cause suppression of mucosal immune parameters (1)
. We investigated the effect of astaxanthin
(Asx) supplementation on salivary IgA (sIgA) concentration and secretion rate in ...
Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder
(Nature Publishing Group, 2015)
Subtle mood fluctuations are normal emotional experiences, whereas drastic mood swings can be a manifestation of bipolar disorder (BPD). Despite their importance for normal and pathological behavior, the mechanisms underlying ...
The role of toxic metals and metalloids in nrf2 signaling
(MDPI AG, 2021)
Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resis-tance to oxidants, serves as one of the key defensive factors against a range of pathological processessuch as oxidative damage, ...
Premature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Age
(Oxford Univ Press Inc, Cary, 2010)
Chromosomal alterations are a feature of both aging and Alzheimer's disease (AD). This study examined if premature centromere division (PCD), a chromosomal instability indicator increased in AD, is correlated with aging ...
Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures
(Springer Verlag, 2019)
Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as ...
Bcs class iv oral drugs and absorption windows: Regional-dependent intestinal permeability of furosemide
(MDPI AG, 2020)
Biopharmaceutical classification system (BCS) class IV drugs (low-solubility low-permeability) are generally poor drug candidates, yet, ~5% of oral drugs on the market belong to this class. While solubility is often ...
Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype
(MDPI, 2021)
The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to ...