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Bcs class iv oral drugs and absorption windows: Regional-dependent intestinal permeability of furosemide
(MDPI AG, 2020)
Biopharmaceutical classification system (BCS) class IV drugs (low-solubility low-permeability) are generally poor drug candidates, yet, ~5% of oral drugs on the market belong to this class. While solubility is often ...
Premature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Age
(Oxford Univ Press Inc, Cary, 2010)
Chromosomal alterations are a feature of both aging and Alzheimer's disease (AD). This study examined if premature centromere division (PCD), a chromosomal instability indicator increased in AD, is correlated with aging ...
Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis
(Springer Nature Switzerland, 2020)
Drug-induced Mood- and Cognition-related adverse events (MCAEs) are often only detected during the clinical trial phases of drug development, or even after marketing, thus posing a major safety concern and a challenge for ...
Potential applications of NRF2 modulators in cancer therapy
(MDPI, 2020)
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1 (KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from oxidative, electrophilic, and xenobiotic ...
Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs
(Blackwell Publishing Inc., 2019)
Background: Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Hypothesis: Dogs with B. canis-induced APR ...
Drug use before and during pregnancy in republic of Serbia
(Elsevier, 2009)
OBJECTIVES: To investigate drug use six months before (SMBP) and during preg-
nancy (DP) among Serbian pregnant women (SPW). METHODS: Pharmacy based
cross-sectional survey was conducted among SPW between March through ...
Beta CCT as well as flumazenil prevent the diazepam withdrawal-induced anxiety in the elevated plus maze in rats
(Oxford Univ Press, Oxford, 2012)
Objective : Despite a half century of clinical use and the recognized
potential of benzodiazepine dependence, the mechanisms under-
lying benzodiazepine withdrawal remain insufficiently understood.
The aim of the present ...
Sources of information and pharmacists' knowledge regarding rare diseases and orphan drugs: cross-sectional study in Serbia
(Elsevier, 2014)
Objectives: The lack of information and scientific knowledge of rare diseases (RDs)
and orphan drug (ODs) could affect the quality of health care delivered to patients suf-
fering from rare diseases. The aim of this study ...
Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach
(Elsevier Science Inc, 2014)
Objectives: Colistimethate sodium (Colistin) is an old, “forgotten” antibiotics
revived due to multidrug-resistant Gram-negative bacteria in nosocomial infec-
tions. In many countries, both – intravenous and inhalational ...
Correlation between oxidative stress and biomarkers of joint damage in patients with severe haemophilia treated by different prophylaxis regimens
(Ferrata Storti Foundation, Pavia, 2014)
Background: Haemophilic arthropathy is the main cause of morbidity in indi-
viduals with severe haemophilia and prevention of joint disease is the primary
goal of treatment. Recurrent bleeding into joints causes damage ...