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Design and characterization of a novel structural class of Kv1.3 inhibitors
(Elsevier, 2020)
The voltage-gated potassium channel Kv1.3 is involved in multiple autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, diabetes mellitus type 1 and psoriasis. In many auto-immune diseases better treatment ...
Spectroscopic studies on the drug–drug interaction: the influence of fluoroquinolones on the affinity of tigecycline to human serum albumin and identification of the binding site
(Springer, 2020)
bstract: Concomitant use of two or more drugs in therapy is becoming a more frequent phenomenon and clinically relevant drug–drug interactions at the level of binding to human serum albumin (HSA) are more often. The influence ...
Discovery of membrane permeability, pharmacokinetics properties and mechanism of action for analogs of ethylenediamine-n,n′-di-2-(3-cyclohexyl)propionic acid and 1,3-propandiamine-n,n′-di-2-(3-cyclohexyl)propionic acid with antiproliferative activity using In Vitro and In Silico Methods
(Springer Verlag, 2020)
In previously in vitro studies on different cell lines and in vivo on melanoma and 4T1 murine breast cancer and metastasis it was shown antiproliferative activity for ester derivatives of (S,S)-ethylenediamine-N,N′-di-2- ...
Predicting drug release from diazepam FDM printed tablets using deep learning approach: Influence of process parameters and tablet surface/volume ratio
(Elsevier B.V., 2021)
The aim of this study was to apply artificial neural networks as deep learning tools in establishing a model for understanding and prediction of diazepam release from fused deposition modeling (FDM) printed tablets. Diazepam ...
An electrochemical study of 9-chloroacridine redox behavior and its interaction with double-stranded DNA
(Elsevier B.V., 2020)
The electrochemical behavior of 9-chloroacridine (9Cl-A), a precursor molecule for synthesis of acridine derivatives with cytostatic activity, is a complex, pH-dependent, diffusion-controlled irreversible process. Oxidation ...
What role does carbonized tannic acid play in energy storage composites?
(Elsevier Ltd, 2022)
Transformation of tannic acid (TA), a cheap, abundant and environmentally friendly (by)product, upon carbonization at various temperatures was examined as it is extensively being used in energy storing devices. In addition ...
Chemical Composition of Volatiles of Eight Geranium L. Species from Vlasina Plateau (South Eastern Serbia)
(Wiley-VHCA AG, 2020)
Geranium species are widely used in traditional medicine of Balkan. The aim of this work was to investigate and compare chemical composition of volatile fractions obtained by hydrodistillation from aerial parts of G. ...
Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery
(Elsevier B.V., 2021)
The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic ...
Double active BEA zeolite/silver tungstophosphates – Antimicrobial effects and pesticide removal
(Elsevier, 2020)
Novel composites of BEA zeolite and silver tungstophosphate were prepared by different procedures: two-step impregnation, ion-exchange, and as physical mixtures with varying component mass ratios. Composites were characterized ...
Sex-specific remodeling of T-cell compartment with aging: Implications for rat susceptibility to central nervous system autoimmune diseases
(Elsevier B.V., 2021)
The incidence of multiple sclerosis (MS) and susceptibility of animals to experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model of MS, decrease with aging. Generally, autoimmune diseases ...