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A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products
dc.creator | Antić, Dušan | |
dc.creator | Filipić, Slavica | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-02T11:10:48Z | |
dc.date.available | 2019-09-02T11:10:48Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1233-2356 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/970 | |
dc.description.abstract | A simple, conventional TLC method has been established for separation of clopidogrel and its hydrolytic product SR 26334, the main impurity in clopidogrel. Use of aluminium. foil-backed silica gel 60F(254) plates with n-heptane-tetrahydrofuran, 1:1 (v/v), as mobile phase, enabled successful separation of clopidogrel in high excess from the impurity. The separated compounds were detected at 230 nm. Regession coefficients (r >= 0.999), recovery (94.5-107.1%), and limit of quantification (0.047 mg mL(-1)) were evaluated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of clopidogrel both in raw material and in dosage forms. | en |
dc.publisher | Univ Silesia, Inst Chemistry, Katowice | |
dc.rights | restrictedAccess | |
dc.source | Acta Chromatographica | |
dc.title | A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Филипић, Славица; Aнтић, Д.; Aгбаба, Даница; | |
dc.citation.volume | 18 | |
dc.citation.spage | 199 | |
dc.citation.epage | 206 | |
dc.citation.other | 18: 199-206 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000249705200017 | |
dc.identifier.scopus | 2-s2.0-34548263684 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_970 | |
dc.type.version | publishedVersion |
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