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Multicriteria optimization methodology in development of HPLC separation of mycophenolic acid and mycophenolic acid glucuronide in human urine and plasma
(Elsevier Science BV, Amsterdam, 2009)
Multicriteria optimization methodology was applied for development of isocratic reversed-phased HPLC method for simultaneous determination of mycophenolic acid (MPA) and mycophenolic acid glucuronide (MPAG) in human urine ...
Application of experimental design in optimization of solid phase extraction of mycophenolic acid and mycophenolic acid glucuronide from human urine and plasma and SPE-RP-HPLC method validation
(Elsevier Science BV, Amsterdam, 2008)
The aim of this study was to develop and optimize a solid phase extraction (SPE) procedure for purification of mycophenolic acid (MPA) and its metabolite mycophenolic acid glucuronide (MPAG) in biological samples. During ...
Determination of paracetamol in pure and pharmaceutical dosage forms by pulse perturbation technique
(Elsevier Science BV, Amsterdam, 2006)
A new procedure for kinetic determination of paracetamol in pharmaceuticals is proposed. The method is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system being in a stable ...
Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 ...
High-performance liquid chromatographic method for the determination of moclobemide and its two major metabolites in human plasma
(Elsevier Science BV, Amsterdam, 2007)
A selective, sensitive, and simple high-performance liquid chromatographic (HPLC) method was developed for the determination of moclobemide and its two major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma. Sample ...
Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically ...
Isocratic RP-HPLC method for rutin determination in solid oral dosage forms
(Pergamon-Elsevier Science Ltd, Oxford, 2007)
A rapid and sensitive assay for quantitative determination of rutin in oral dosage forms based on isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed and validated. Using a C-18 reverse-phase ...
Trace elements analysis of Echinacea purpurea - herbal medicinal
(Elsevier Science BV, Amsterdam, 2003)
Elemental composition of Echinacea purpurea (Asteracae), grown in Serbia under strongly controlled conditions, has been studied. To distinguish elemental patterns of different parts of the plant, the content of Zn, Fe, Cu, ...
Photochemical degradation of solid-state nisoldipine monitored by HPLC
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times ...
Acidity constants of cefetamet, cefotaxime and ceftriaxone; the effect of the substituent at C3 position
(Elsevier Science BV, Amsterdam, 2005)
Ionization constants of three cephalosporin antibiotics, cefetamet (CEF), cefotaxime (CFX) and ceftriaxone (CFTR) are determined using pH-potentiometric titrations at I= 0.1 M (NaCl) and t = 25 degrees C. Cefetarnet and ...