Претраживање
Приказ резултата 11-20 од 32
A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation / Pun faktorski dizajn u formulaciji parenteralnih nanoemulzija sa diazepamom - fizičkohemijska karakterizacija i procena stabilnosti
(Univerzitet u Nišu - Tehnološki fakultet, Leskovac, 2015)
Using the experimental design methodology, we have developed and characterized nanoemulsions for a parenteral delivery using diazepam as a model drug. The formulations containing 20 or 30% (w/w) of medium chain triglycerides ...
Physicochemical Factors Governing the Partition of Pramipexole and Its Five Impurities in Microemulsion Liquid Chromatographic Systems
(Soc Brasileira Quimica, Sao Paulo, 2012)
Microemulsions when used as mobile phases represent a very powerful chromatographic tool due to their polyphase structure. The aim of this study was to investigate the influence of the mobile phase composition and resulting ...
Statistical optimization applied to simultaneous determination of maprotiline, desipramine, and moclobemide by capillary zone electrophoresis
(Springer Wien, Wien, 2008)
A method of Capillary Zone Electrophoresis (CZE) for separation of three most-frequently prescribed antidepressants in the market: maprotiline, desipramine, and moclobemide was developed. The proposed method is fully ...
Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers
(Vieweg, Wiesbaden, 2007)
An HPLC method has been developed for the separation of valdecoxib and a degradation product consisting of alpha and beta-N-lactosyl sulfonamide, i.e. alpha and beta anomers (SC-77852). Best results were achieved with a ...
Central Composite Design with/without Artificial Neural Networks in Microemulsion Liquid Chromatography Separation Robustness Testing
(Slovensko Kemijsko Drustvo, Ljubljana, 2009)
In past few years, for overcoming some analytical problems in liquid chromatography, the microemulsion as eluent was employed. Due to the strict regulatory requirements, robustness testing became important especially when ...
Using experimental design in optimisation of VIS spektrophotometric method of investigation feroglicin sulfate in Orferon retard tablets / Primena eksperimentalnog dizajna u optimizaciji VIS spektrofotometrijske metode za određivanje feroglicin sulfata u Orferon retard tabletama
(Savez farmaceutskih udruženja Srbije, Beograd, 2004)
Iron preparations are used in the treatment or prophylaxis of sideropenic anemia developed due to insuficiency of iron in the body. They can be used orally (tablets, capsules, suspensiones, wines ) and parenterally. The ...
Stepwise optimization approach for improving LC-MS/MS analysis of zwitterionic antiepileptic drugs with implementation of experimental design
(Wiley-Blackwell, Hoboken, 2013)
In this article, a step-by-step optimization procedure for improving analyte response with implementation of experimental design is described. Zwitterionic antiepileptics, namely vigabatrin, pregabalin and gabapentin, were ...
Development and optimization of formulation for treatment of copper deficiency in human organism
(Polskie Towarzystwo Farmaceutyczne, Warsaw, 2012)
The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation ...
Impurity profiling of mycophenolate mofetil with the assisstance of desirability function in method development
(Taylor & Francis Inc, Philadelphia, 2011)
Multicriteria decision making methodology in combination with experimental design has been applied for optimization of stability-indicating LC/DAD method of Mycophenolate mofetil and its degradation products. Via fractional ...
Experimental design in reversed-phase high-performance liquid chromatographic analysis of imatinib mesylate and its impurity
(Elsevier Science BV, Amsterdam, 2004)
For the determination of the optimal RP-HPLC chromatographic conditions for the separation of imatinib mesylate and its impurity STI 509-00 experimental design 2(4) was applied. All the factors that affect imatinib ...