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Protective effects of fruit wines against hydrogen peroxide—induced oxidative stress in rat synaptosomes
(MDPI AG, 2021)
This study aimed to evaluate, in vitro, the antioxidative potential of fruit wines produced from berry fruits (i.e., black chokeberry, blueberry, blackberry, and raspberry), cherry, and apple by different technological ...
Influence of Higenamine on Exercise Performance of Recreational Female Athletes: A Randomized Double-Blinded Placebo-Controlled Trial
(Frontiers Media S.A., 2021)
The aim of this study was to determine the ergogenic effects and the safety profile of a one-component higenamine supplement in female recreational athletes. Twelve recreational female basketball players (age 29–41 years, ...
The impact of treatment choices on potential drug–drug interactions in hypertensive patients
(John Wiley and Sons Inc, 2021)
Aims: The aim of this study was to analyse potential drug–drug interactions (pDDIs) and their potential adverse drug reactions (ADRs) among hypertensive patients. Moreover, we investigated the possibility of reducing pDDIs ...
Vasodilatory effects of a variety of positive allosteric modulators of GABAA receptors on rat thoracic aorta
(Elsevier B.V., 2021)
Different subtypes of GABAA (gamma-aminobutyric acid A) receptors, through their specific regional and cellular localization, are involved in the manifestation of various functions, both at the central and peripheral levels. ...
Improving tableting performance of lactose monohydrate by fluid-bed melt granulation co-processing
(MDPI, 2021)
Co-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression. This study aimed to improve tableting characteristics ...
Development of lipid-based gastroretentive delivery system for gentian extract by double emulsion–melt dispersion technique
(MDPI, 2021)
Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and ...
Revealing the role of high-density lipoprotein in colorectal cancer
(MDPI AG, 2021)
Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology,which includes metabolic alterations as contributors to disease development. Studies have shownthat lipid status disorders are involved ...
Antiallergic Treatment of Bariatric Patients: Potentially Hampered Solubility/Dissolution and Bioavailability of Loratadine, but Not Desloratadine, Post-Bariatric Surgery
(American Chemical Society, 2022)
Gastrointestinal anatomical/physiological changes after bariatric surgery influence variables affecting the fate of drugs after ingestion, and medication management of these patients requires a thorough and complex mechanistic ...
MFI, BEA and FAU zeolite scavenging role in neonicotinoids and radical species elimination
(The Royal Society of Chemistry, 2022)
Ecotoxicity caused by neonicotinoid pesticides is largely due to oxidative stress on non-target species. Due to the fact that reactive radical species reach the environment, materials intended for pesticide removal should ...
3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction
(MDPI, 2021)
Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was ...