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Aging impairs endocytic capacity of splenic dendritic cells from Dark Agouti rats and alters their response to TLR4 stimulation
(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2015)
The study was undertaken considering: i) that relative proportion of distinct subsets of splenic dendritic cells (DCs) is strain-specific and predictive for the susceptibility to autoimmune diseases; ii) age-related changes ...
Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
(MDPI, Basel, 2013)
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization ...
Expectations, concerns, and needs of patients who start drugs for chronic conditions. A prospective observational study among community pharmacies in Serbia
(Taylor & Francis Ltd, Abingdon, 2017)
Background: During the initiation of treatment of a chronic disease, patients may have varying interests, expectations, concerns, and reasons to stop treatment, influencing compliance with prescribed treatment. Thus, ...
Five different columns in the analysis of basic drugs in hydrophilic interaction liquid chromatography
(Versita, Warsaw, 2013)
Five different columns (two silica, two cyanopropyl and one diol) were investigated in hydrophilic interaction liquid chromatography (HILIC). For the assessment of columns behavior in HILIC mode, six basic drugs (lamotrigine, ...
Direct Spectrophotometric Determination of Hesperidin in Pharmaceutical Preparations
(Slovensko Kemijsko Drustvo, Ljubljana, 2012)
A simple, rapid and reliable direct spectrophotometric method for the determination of hesperidin is proposed and validated. The influence of wavelength, solvent, the ionic strength, pH and temperature on hesperidin ...
Multiple Targeting Approaches on Histamine H-3 Receptor Antagonists
(Frontiers Media Sa, Lausanne, 2016)
With the very recent market approval of pitolisant (Wakix (R)), the interest in clinical applications of novel multifunctional histamine H-3 receptor antagonists has clearly increased. Since histamine H-3 receptor antagonists ...
A subpopulation that may correspond to granulocytic myeloid-derived suppressor cells reflects the clinical stage and progression of cutaneous melanoma
(Oxford Univ Press, Oxford, 2016)
Seventy-eight melanoma patients and 10 healthy individuals were examined. Follow-up examinations of all melanoma patients were performed regularly every three months. Myeloid-derived suppressor cells (MDSC) were defined ...
One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug
(Frontiers Media Sa, Lausanne, 2016)
Alzheimer's Disease is a complex and multifactorial disease for which the mechanism is still not fully understood. As new insights into disease progression are discovered, new drugs must be designed to target those aspects ...
Authors' reply to 'Granulocytic myeloid-derived suppressor cells in peripheral blood of patients with cutaneous melanoma'
(Oxford Univ Press, Oxford, 2016)
Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: The approximated activation of receptor subtypes may explain behavioral effects
(Elsevier Science BV, Amsterdam, 2014)
Enormous progress in understanding the role of four populations of benzodiazepine-sensitive GABA(A) receptors was paralleled by the puzzling findings suggesting that substantial separation of behavioral effects may be ...