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Optimization of an RP-HPLC method for drug control analysis
(Marcel Dekker Inc, New York, 2003)
Optimization of important conditions for the reversed-phase high-performance liquid chromatographic method was done for the separation of the active ingredients in Marcaine(R) adrenaline injections (bupivacaine hydrochloride ...
Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study
(Taylor & Francis Inc, Philadelphia, 2009)
A SPE-HPLC-UV method for determination of moclobemide and its major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma had been developed previously and its selectivity was evaluated against the most frequently ...
An Experimental Design Approach to Selecting the Optimum HPLC Conditions for the Determination of 2-Arylimidazoline Derivatives
(Taylor & Francis Inc, Philadelphia, 2009)
In order to improve the chromatographic resolution (Rs) with a good analysis time, experimental designs were applied for multivariate optimization of the experimental conditions of an isocratic reversed phase high performance ...
Forced degradation studies of simvastatin using microemulsion liquid chromatography
(Taylor & Francis Inc, Philadelphia, 2010)
In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such ...
Robustness Testing of Microemulsion Liquid Chromatographic Separation of Simvastatin and its Impurities
(Taylor & Francis Inc, Philadelphia, 2009)
Liquid chromatography employing the microemulsion as eluent was applied for the analysis of simvastatin and its six impurities. Previously, the optimized and validated method was tested to prove the method's capability to ...
Monitoring of impurity level of valsartan and hydrochlorothiazide employing an RP-HPLC gradient mode
(Taylor & Francis Inc, Philadelphia, 2007)
The multi-component preparation Co -Diovan (R) is indicated for the hypertension treatment in patients whose blood pressure is not adequately controlled by monotherapy. Its active ingredients are valsartan and hydrochlorothiazide. ...
Forced degradation study of torasemide: Characterization of its degradation products
(Taylor & Francis Inc, Philadelphia, 2013)
Torasemide was subjected to forced degradation studies. Stress conditions were varied concerning hydrolysis (acid, base, and neutral), oxidation, photolysis, and thermal degradation in order to identify the potential ...
TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals
(Taylor & Francis Inc, Philadelphia, 2012)
A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and ...
TLC determination of glimepiride and its main impurities in pharmaceuticals
(Taylor & Francis Inc, Philadelphia, 2013)
A quantitative TLC method was developed for the simultaneous separation and quantification of glimepiride and its main degradation impurities, glimepiride-sulfonamide, and glimepiride-carbamate. Chromatographic analysis ...
Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography
(Taylor & Francis Inc, Philadelphia, 2019)
The retention behavior of ivabradine, its 11 related compounds, diltiazem and verapamil has been examined by thin-layer chromatography using non-polar stationary phase (RP-18) and the following mobile phases: methanol-6.25% ...